The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD

Inclusion criteria

• Male or Female aged ≥ 20 years
• Reflux esophagitis with erosion or ulceration confirmed by endoscopic exam.
• Refractory reflux esophagitis to PPIs standard treatment as follows

• Ongoing heartburn symptom with or without these GERD-related symptoms : Regurgitation, Non-cardiac chest pain, Epigastric pain, Belching, Bloating, Satiety, Sore throat, Cough, Laryngitis, Hoarseness, Nausea, Vomiting, Dysphagia, Odynophagia, Weight loss
• Ongoing heartburn symptom with or without erosion ≥ grade A according to LA Classification
• Ongoing heartburn symptoms ≥ 2 days during 1week right before administering first dose of IP
• Decided to participate and signed on an informed consent form willingly

Exclusion criteria

• Existence of upper gastrointestinal bleeding or active gastroduodenal ulcer at screening
• History of operation in esophagus, stomach or duodenum
• The following medical history

• Primary esophageal motility disease, Achalasia, Scleroderma, Esophageal/pyloric stricture, Primary esophageal spasm
• Barrett's esophagus ≥ 3 cm
• Zollinger-Ellison syndrome
• Infectious or inflammatory bowel disease, Severe malabsorption
• Severe chronic heart failure, cardiovascular disease, renal failure, COPD, asthma, liver cirrhosis
• History of cancer within 5 years, except completely recovered skin cancer
• ALT or AST ≥ Upper limit of normal range X 3
• Need antibiotics due to severe infection
• Severe medical disease that needs these prohibited medication

• Anticoagulant(Heparin, Warfarin, etc.), High dose of aspirin(>325mg/d), Digitalis(Digoxin, etc.), Diuretics, Atazanavir, NSAIDs or Steroids
• Use PPIs or H2RA medicine within 1 week before administering first dose of IP, or need other PPIs or H2RA medicine during trial period
• Allergy or hypersensitivity to IP or similar chemical structure(Benzimidazol derivatives, etc.)
• Pregnant or breast-feeding women
• Conversation impairment because of alcohol, drug addiction or mental illness, etc.
• Administration of other IP within 28 days
• Inability to record heartburn diary card
• In investigator's judgement