The Ganzhou City People's Hospital
Ganzhou, Jiangxi, 8112320, China
Location status: Recruiting
Recruiting
NCT Number: NCT06704334
The Study of Ginkgo Leaf Dropping Pills and Huperzine a Injection Combined with Median Nerve Electrical Stimulation in the Treatment of Cognitive Impairment After Brain Injury
This study will conduct a single-center clinical trial to explore the initial therapeutic effect of ginkgo biloba dropping pills, huperzine A injection and median nerve electrical stimulation in patients with cognitive impairment.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–80 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Phase 4
Primary location
About this study
Specific experimental research methods were randomized, controlled, single-center, exploratory clinical study, through the treatment of ginkgo biloba dropping pills, huperzine A injection and median nerve electrical stimulation in patients with cognitive impairment, to observe the effects of their neuroprotection and cognitive function improvement.
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Be over 18 years old
- Residual cognitive impairment due to brain injury
- No previous history of brain-related diseases except this one
Exclusion criteria
- The patient had severe underlying disease and unstable vital signs
- The patient was complicated with consciousness disorder and could not cooperate with cognitive function assessment ③ Allergic to drugs or contraindications in drug use ④ There are contraindications of median nerve electrical stimulation
Treatment and study plan
Median nerve electrical stimulation treatment
OtherMedian nerve electrical stimulation is an electrical stimulation therapy in which the electrode is placed at the median nerve point 2cm above the carpal wrinkles on the palmar surface of the wrist joint. Generally, the right median nerve is used for electrical stimulation. Electrical stimulation improves cognitive function by stimulating neurons in the brain and improving information transmission between neurons. When electrical current stimulates the brain, it can increase the activity level of neurons and promote the signal transmission between neurons. Its mechanism of action includes the regulation of neurotransmitter acetylcholine, thereby enhancing cognitive function.
Huperzine A injection
Drugintramuscular
Ginkgo leaf dropping pill
Drugoral
Primary outcomes
-
to assess the MMSE score
Time frame: baseline，Day10，Day90
Secondary outcomes
-
to assess the MoCA score
Time frame: baseline，Day10，Day90
-
to assess the ADAS-cog score
Time frame: baseline，Day10，Day90
-
to assess the HAMD score
Time frame: baseline，Day10，Day90
-
to assess the HAMA score
Time frame: baseline，Day10，Day90
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Wanbangde Pharmaceutical Group Co., LTD
Industry
Collaborators
- Ganzhou City People's Hospital
Registry information
Important dates
- Study start
- 2024
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Nov 26, 2024
- Registry last updated
- Dec 11, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.