The Study of ENB With Ultra-thin Cryobiopsy in the Diagnosis of Peripheral Pulmonary Nodules

This project intends to carry out a national multicenter randomized controlled study, with traditional forceps biopsy as the control group and cryobiopsy as the experimental group, to verify the feasibility, effectiveness and safety of electromagnetic navigation bronchoscope-guided cryobiopsy in the diagnosis of peripheral pulmonary nodules, so as to provide an efficient and minimally invasive diagnostic method for the diagnosis of peripheral pulmonary nodules

Inclusion criteria

• age 18 to 90 years;
• pulmonary nodules detected by chest CT, suspected malignant nodules or unknown cause should be confirmed by biopsy;
• chest CT showed that the nodule was located in the segmental bronchus and below, and the maximum diameter of the nodule was 8 mm to 30 mm.It was not accessible by conventional bronchoscopy;
• if chest CT showed multiple pulmonary nodules, one of the pulmonary nodules was selected as the target lesion.

Exclusion criteria

• contraindications to the bronchoscopy procedure;
• high risk of bleeding, such as bronchial artery penetration or suspected lung metastasis of renal cell carcinoma;
• electromagnetic source implanted in the body;
• contraindications to anesthesia;
• pregnant woman;
• participated in other studies within three months and did not withdraw or finish, affect the observation of this study;
• inability or unwillingness to provide informed consent or comply with the follow-up schedule.