Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
Location status: Recruiting
Recruiting
NCT Number: NCT06944418
The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases
The study subjects of this research are patients with eosinophil-associated pulmonary diseases, including eosinophilic granulomatosis with polyangiitis, idiopathic hypereosinophilic syndrome, idiopathic acute eosinophilic pneumonia, idiopathic chronic eosinophilic pneumonia, and primary simple pulmonary eosinophilia. The aim is to detect eosinophil subtypes in peripheral blood based on surface protein expression, to understand the differences in eosinophil subtypes among patients with different diseases, to elucidate the significance of different eosinophil subtypes, and ultimately to provide a theoretical basis for the selection of treatment directions for patients.
Recruiting
Interested in participating?
Request InfoKey information
Age range
18 year–90 year
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- For Healthy Volunteers: healthy volunteers matching the age and gender of the study subjects
- For EPD: ① Persistent eosinophil count increase>1500 per cubic millimeter for more than 6 months. ② Lack of evidence of a secondary cause of eosinophilia is required. ③ Signs and symptoms of end-organ damage presumed to be secondary to eosinophilia
Exclusion criteria
- Patients with concurrent definitive pulmonary infections, malignancies, or other parenchymal lung diseases;
- Patients who are unable or unwilling to cooperate with the collection of clinical information (e.g., due to mental disorders, memory impairments, etc.);
- Patients who are unable to provide informed consent.
Treatment and study plan
observation
Otherobservation
Primary outcomes
-
Proportion of Eosinophil Subtypes in Serum
Time frame: From January 1, 2024 to January 1, 2027
Proportion of Eosinophil Subtypes in Serum Before and After Treatment in Patients
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Peking Union Medical College Hospital
Other
Registry information
Official study title
The Study of Differences in Eosinophil Function and Subsets in Patients With Eosinophilic Pulmonary Diseases Based on Flow Cytometry Analysis
Important dates
- Study start
- 2024
- Primary completion
- 2026
- Study completion
- 2027
- First posted
- Apr 25, 2025
- Registry last updated
- Apr 25, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.