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NCT Number: NCT04662437

The Status of Parathyroid Hormone Secretion in Covid-19 Patients

COVID-19 infection causes a hypersensitive immune reaction and widespread inflammation in various organs of the body, especially through cytokines in the lungs. This cytokine-mediated widespread inflammation can also affect the parathyroid glands, resulting in impaired parathyroid secretion.

Researchers evaluated the levels of parathyroid hormone, calcium, phosphorus, and alkaline phosphatase in patients hospitalized for COVID-19 infection. Researchers excluded patients on intensive care therapy and patients with known parathyroid disease.

The researchers examined the association of parathyroid hormone secretion with COVID-19 disease, white blood cells, neutrophil / lymphocyte ratio, C reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone level of healthy people without COVID-19 infection and known parathyroid disease with the parathyroid hormone level of Covid-19 patients.

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Key information

Conditions

COVID-19 Infection Alkaline Phosphatase COVID-19 Calcium Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Parathyroid Gland Parathyroid Hormone Phosphorus Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Bezmialem VU

Istanbul, 34093, Turkey (Türkiye)

About this study

The coronavirus-2 (SARS-COV-2) virus, which can cause severe acute respiratory syndrome through the droplet, has caused the global Coronavirus 19 (COVID-19) pandemic. COVID-19 infection can be asymptomatic or lead to serious illness and even death. This virus causes a hypersensitive immune reaction and varying degrees of widespread inflammation through cytokines in various organs of the body, mainly the lungs.

Cytokine-mediated widespread inflammation caused by the virus may also affect the parathyroid glands, causing their functions to deteriorate. Thus, it may cause changes in parathyroid hormone secretion.

The researchers evaluated the results of serum parathyroid hormone, calcium, phosphorus, alkaline phosphatase tests in patients who were symptomatic and hospitalized with COVID-19 infection. Participants also evaluated the relationship of parathormone with white blood cells, neutrophil / lymphocyte ratio, c reactive protein, fibrinogen, procalcitonin, ferritin, and D-dimer in these patients. The researchers compared the parathyroid hormone levels of patients with COVID-19 infection with the parathyroid hormone levels of healthy individuals without COVID-19 infection and parathyroid disease. So the investigators looked for differences in parathyroid hormone levels between both groups. Researchers did not include patients in the intensive care unit and patients with known parathyroid disease.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To accept research.
  • Being over the age of 18.
  • COVID 19 test results to be positive.
  • Not taking parathyroid disease medication before.
  • Receiving inpatient treatment in the COVID service in the hospital.

Exclusion criteria

  • Not accepting research.
  • Be under the age of 18.
  • Negative COVID 19 test results for patients.
  • COVID patients treated as outpatient.
  • Parathyroid disease in the healthy control group.

Treatment and study plan

Venous blood was collected for biochemistry testing

Diagnostic Test

From the people in the healthy control group, 10 ml of venous blood was collected from the venous vein in the forearm of all individuals in the study. Parathyroid hormone, calcium, phosphorus, alkaline phosphatase levels were measured from this blood.

Primary outcomes

  1. Comparison of parathyroid hormone between groups

    Time frame: 90 days

    In the study, serum parathyroid hormone results of the Covid patient group and non-Covid control groups were recorded and compared statistically.

  2. Comparison of calcium between groups

    Time frame: 90 days

    In the study, serum calcium results of the Covid patient group and non-Covid control groups were recorded and compared statistically.

  3. Comparison of phosphorus between groups

    Time frame: 90 days

    In the study, serum phosphorus results of the Covid patient group and non-Covid control groups were recorded and compared statistically.

  4. Comparison of alkaline phosphatase between groups

    Time frame: 90 days

    In the study, serum alkaline phosphatase results of the Covid patient group and non-Covid control groups were recorded and compared statistically.

  5. White blood cells (WBC) results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum WBC results were recorded in Covid 19 patient groups.

  6. Neutrophil / lymphocyte ratio (N/LO) results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum N/LO results were recorded in Covid 19 patient groups.

  7. C-reactive protein (CRP) results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum CRP results were recorded in Covid 19 patient groups.

  8. Fibrinogen results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum fibrinogen results were recorded in Covid 19 patient groups.

  9. Procalcitonin results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum procalcitonin results were recorded in Covid 19 patient groups.

  10. Ferritin results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum ferritin results were recorded in Covid 19 patient groups.

  11. D-dimer results of Covid 19 patient group

    Time frame: 90 days

    In the study, serum D-dimer results were recorded in Covid 19 patient groups.

Sponsors and collaborators

Lead sponsor

Bezmialem Vakif University

Other

Collaborators

  • Didem Ertorul

Registry information

Official study title

The Status of Parathyroid Hormone Secretion and Its Relationship With White Blood Cells, Neutrophil / Lymphocyte Ratio, c Reactive Protein, Fibrinogen, Procalcitonin, Ferritin and D-dimer in Hospitalized Covid-19 Patients

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Dec 10, 2020
Registry last updated
Dec 10, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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