The SEAS Study: Sensory Engagement and Activation During Noninvasive Stimulation

This pilot early feasibility study in healthy participants is intended to establish quantitative physiological markers of cortical and autonomic modulation evoked by noninvasive electrical and/or ultrasound stimulation of the nervous system.

Inclusion criteria

• Able to provide written informed consent in English.
• Willing and able to complete study procedures (e.g., ~1-hour sessions with non-invasive recordings, ~3-hour visit).

Exclusion criteria

• History of neurological disorders (e.g., epilepsy, migraines) or psychiatric conditions requiring medication.
• Active implanted medical devices (e.g., pacemakers, cochlear implants) or metal in the neck/forearm that could interfere with stimulation or recordings.
• Skin conditions or open wounds at stimulation sites (cervical neck, forearm).
• Women who are pregnant or breastfeeding.
• Current use of medications affecting autonomic or cortical function (e.g., beta-blockers, sedatives).
• Inability to sit still for recordings or understand instructions (e.g., due to severe vision/hearing impairment).