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NCT Number: NCT07560592

The Salt Study for Heart Failure

The purpose of this study is to understand if low sodium (cardiac) diet is indeed necessary for better health outcomes in patients who suffered heart failure. This study will investigate the association between sodium intake and risk for 30-day re-admission in Heart Failure (HF) patients.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Robert Wood Johnson Barnabas Hospital - New Brunswick

New Brunswick, New Jersey, 08901, United States

Location status: Recruiting

Location contact

Manisha Bajpai, PhD

CONTACT

[email protected]

Maya Guglin, MD

CONTACT

[email protected]

8483915776

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Above 18 years of age
  • Hospitalization due to Heart Failure admitted within 24 hours

Exclusion criteria

  • Concomitant hypertension (blood pressure >150/90 mmHg on admission)
  • End stage renal disease (on hemodialysis or peritoneal dialysis
  • Cardiogenic shock

Treatment and study plan

Normal Salt Diet

Other

This study will allow regular diet 3-4 g Na-Salt per day in patients with acute HF as an intervention, because the standard recommendation for such patients is cardiac diet with 2 g Na per day. The intervention will end when the patient is discharged from the hospital. They will follow routine clinical care recommendations after discharge from hospital.

Cardiac Diet

Other

This arm of study will allow the cardiac diet with 2 g Na per day, that is standard recommendation for HF patients. They will follow routine clinical care recommendations after discharge from hospital.

Primary outcomes

  1. Length of hospital stay

    Time frame: Hospital admission to time of discharge assessed up to 1 year

    number of days the patient remains hospitalized

  2. 30-day readmission

    Time frame: 30 days after discharge from hospital after index event

    readmission to hospital within 30 days of discharge from the index event

  3. NT-proBNP on discharge

    Time frame: time of hospital admission to 30 days after discharge

    Measurement of blood levels of NT-ProBNP a biomarker for diagnosing and assessing the severity of heart failure.

  4. Loop diuretic requirement during index admission

    Time frame: time of hospital admission to 30 days after discharge

    Furosemide, torsemide, and bumetanide are specific loop diuretics used in the treatment of fluid overload / retention conditions like congestive heart failure.

Study contacts

Contact information is provided by the study sponsor or research team.

Manisha Bajpai, PhD

CONTACT

[email protected]

Maya Guglin, MD

CONTACT

[email protected]

8483915776

Sponsors and collaborators

Lead sponsor

Maya Guglin, MD

Other

Registry information

Official study title

Evaluating Effect of Low-Sodium and Regular Diets on Heart Failure Outcomes

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
May 1, 2026
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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