The Safety and Effectiveness of Indinavir Sulfate Plus Efavirenz

It is hypothesized that after 16 weeks of randomized treatment with either the control or experimental regimen that:

• The observed proportion of patients with serum viral RNA < 400 copies/ml in the experimental and control regimen will be similar and will continue to be so after 48 weeks.
• The safety profiles of the two groups will be similar, judged by the incidence of serious, drug-related adverse experiences and the incidence of events of specific interest (e.g., nephrolithiasis, hyperbilirubinemia, nausea/vomiting, rash, and CNS-related symptoms) and will continue to be so after 48 weeks.
• The two groups will be similar with respect to changes from baseline in serum viral RNA and CD4 counts and will continue to be so after 48 weeks.

Patients are randomized to one of two regimens: a control regimen of indinavir plus DMP 266 or an experimental regimen of indinavir plus DMP 266, each at different doses than in the control regimen.

Inclusion criteria

Patients must have:

• HIV-1 seropositive status.
• CD4 count >= 100 cells/mm3.
• Serum viral RNA levels >= 10,000 copies/ml.

Exclusion criteria

Prior Medication:

Excluded:

• Prior protease inhibitor therapy.
• Prior non-nucleoside reverse transcriptase inhibitor therapy.