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Completed

NCT Number: NCT03903341

The Role of the Upper Colliculus in the Idiopathic Blepharospasm

This pilot study aims at investigating the role of superior colliculus in patients with idiopathic blepharospasm (BSP) de novo, compared to healthy subjects.

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Key information

Conditions

Blepharospasm, Benign Essential Benign essential blepharospasm

Age range

30 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Grenoble Alpes

Grenoble, 38043, France

About this study

The objective of the study is to investigate the function of the superior colliculus (SC) related to visual stimulation by means of fMRI (functional magnetic resonance imaging) in patients with idiopathic BSP compared to healthy subjects. The hypothesis is that SC function is impaired in BSP (role of biomarker of SC).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Non treated idiopathic blepharospasm
  • Age: 30- 70 years

Exclusion criteria

  • Under the following treatments: Botulin toxin, anticholinergic, benzodiazepines, baclofen, beta- and alpha-blockers collyrium
  • No MRI Contraindication

Treatment and study plan

fMRI

Other

bold signal in visual pathway

Primary outcomes

  1. Visual pathways fMRI

    Time frame: In a five months period after inclusion

    To measure the bold signal in superior colliculus and lateral geniculate corpus

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Official study title

The Role of the Upper Colliculus in the Idiopathic Blepharospasm : a Pilot Study in Functional MRI

Acronym: COLL-BSP

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Apr 4, 2019
Registry last updated
Sep 16, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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