The Role of Serum Anticholinergic Activity in ACVB Patients

Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients. The investigators main goal is to identify preoperative risk factors and to monitor postoperative patients' state in relation to SAA activity and bilateral BIS-EEG changes.

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Key information

Conditions

Acetylcholine BIS-EEG Cognition

Age range

55 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Heidelberg, Department of Anesthesiology, Heidelberg Medical School

Heidelberg, Baden-Wurttemberg, 69120, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

written compliance to the study participation
a good knowledge in German speech
no red/ green blindness
no previous neurological and/or psychiatric illness
good ability to see and to hear
Mini-Mental-State-Examination (MMSE) better than 25 points

Exclusion criteria

no written compliance to the study participation
bad knowledge in German speech
red/ green blindness
previous neurological and/or psychiatric illness
no ability to see and to hear
Mini-Mental-State-Examination (MMSE) lower than 25 points

Treatment and study plan

Primary outcomes

Cognitive dysfunction measured by neurocognitive test battery

Time frame: 3 month postsurgery

Secondary outcomes

SAA, BIS-EEG, descriptive patients' characteristics

Time frame: 24 h postsurgery

Sponsors and collaborators

Lead sponsor

Heidelberg University

Other

Registry information

Official study title

Serum Anticholinergic Activity (SAA) and BIS-EEG as Potential Markers for Cognitive Ability and/or the Anticholinergic Medication in ACVB Patients

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2010
First posted: Oct 31, 2008
Registry last updated: Jan 14, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed