The Role of Milk Derived Peptides on Glycaemic Control

Recent figures estimate 60% of Irish adults are overweight or obese. As obesity is associated with the development of insulin resistance, which precedes type 2 diabetes development by decades, novel food based solutions are required to improve glycaemic control and attenuate insulin resistance.

In the current study insulin resistant individuals will undergo 4 study visits, 1 screening visit and 3 subsequent visits. At each of the 3 visits they will receive an oral lipid load consisting of 100mL soya bean oil, followed by either a water control; the hydrolysate being tested or the parent protein from which the hydrolysate was derived. After which they will undergo a 4 hour hyperinsulinemic-euglycaemic clamp at each visit to assess their insulin sensitivity.

Inclusion criteria

• Age 18 - 65 years
• BMI > 26 kg/m2
• Prepared to maintain a constant body weight for the duration of the study
• Free of any chronic or infectious disease
• Not taking any medication for the regulation of blood sugars
• Diet controlled type 2 diabetes
• Free of any milk allergies or lactose intolerance
• Without anaemia

Exclusion criteria

• <18 or >65 years
• Diabetes (pharmacologically treated) or other endocrine disorders.
• Chronic inflammatory conditions.
• Kidney or liver dysfunction.
• Anaemia (Haemoglobin <12g/dl men, < 11g/dl women).
• Taking any medication for the regulation of blood sugars.