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OpenTrials
Completed

NCT Number: NCT06706830

The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Failure

The goal of this observational study is to evaluate whether the risk of intubation in patients with hypoxemic respiratory failure who were monitored in the intensive care unit and received non-invasive mechanical ventilation and high-flow nasal oxygen treatment could be predicted using lung and diaphragm ultrasound.

The main question it aims to answer is:

Can lung and diaphragm ultrasound predict the risk of intubation in patients with hypoxemic respiratory failure?

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Key information

Conditions

Diaphragm Ultrasonography Hypoxemic Respiratory Failure Lung Ultrasound Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Prof. Dr. Cemil Tascıoglu City Hospital, Istanbul, Şişli, Turkey (Türkiye)

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About this study

Between January 1, 2024, and May 1, 2024, the diaphragm thickness fraction, excursion, LUS score, ROX index, and the LUSS/ROX index ratio were evaluated using lung and diaphragm ultrasound in 91 patients admitted to the intensive care unit with a diagnosis of hypoxemic respiratory failure. These evaluations were performed at the 6th, 12th, 24th, and 48th hours of their ICU stay, and during intubation if the decision for intubation was made

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-PaO2 <60 mmHg detected in arterial blood gas samples at the time of admission to the intensive care unit

Exclusion criteria

  • Under the age of 18
  • History of lung and diaphragm surgery
  • Congenital, acquired or traumatic diaphragmatic hernia
  • Diaphragm paralysis
  • Hemodynamic instability requiring vasoactive drug support
  • Do not agree to participate in the study

Treatment and study plan

Primary outcomes

  1. Lung and diaphragm ultrasound evaluation for risk of intubation

    Time frame: 48 hours

    Lung and diaphragm ultrasound can predict risk of intubation

Secondary outcomes

  1. ROX index evaluation for risk of intubation

    Time frame: 48 hours

    The Respiratory Rate-Oxygenation Index can predict the risk of intubation Higher score means lower risk

  2. LUSS/ROX index ratio evaluation for risk of intubation

    Time frame: 48 hours

    LUSS/ROX index ratio can predict the risk of intubation

Sponsors and collaborators

Lead sponsor

Simge Evren

Other

Registry information

Official study title

The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Patients Receiving High-Flow Nasal Oxygen and Non-Invasive Mechanical Ventilation Support for Hypoxemic Respiratory Failure

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Nov 27, 2024
Registry last updated
Nov 27, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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