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NCT Number: NCT06152497

The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

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Key information

Conditions

Histamine

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of movement and sports sciences, Ghent University, Belgium

Ghent, Oost-Vlaanderen, 9000, Belgium

Location status: Recruiting

Location contact

Wim Derave, Professor

CONTACT

[email protected]

92646326 ext. +32

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male
  • 18-45 years
  • Not to medium physically active

Exclusion criteria

  • Smoking
  • Chronic disease
  • High blood pressure
  • Supplement or medication intake
  • Seasonal allergies
  • Vegetarian / vegan
  • Resistance trained

Treatment and study plan

Placebo

Drug

Oral placebo

H1 blockade: Telfast: 180mg Fexofenadine

Drug

H1 blockade: oral blockade with 180mg Fexofenadine

Resistance training

Behavioral

Resistance training: lower body exercise

Primary outcomes

  1. Muscle volume

    Time frame: Before and after the 10 weeks of resistance training

    Change in muscle volume

  2. Maximal dynamic strength of leg press, bench press, bicep curl and leg curl

    Time frame: Before and after the 10 weeks of resistance training

    Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl

  3. Muscle fiber hypertrophy in muscle biopsies

    Time frame: Before and after the 10 weeks of resistance training

    Change in muscle fiber hypertrophy in muscle biopsies

  4. Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)

    Time frame: Before and after the 10 weeks of resistance training

    Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)

  5. Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)

    Time frame: Before and after the 10 weeks of resistance training

    Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)

Secondary outcomes

  1. Blood pressure (systolic and diastolic)

    Time frame: Before and after the 10 weeks of resistance training

    Chance in Blood pressure (systolic and diastolic)

  2. Resting heart rate

    Time frame: Before and after the 10 weeks of resistance training

    Chance in Resting heart rate

Study contacts

Contact information is provided by the study sponsor or research team.

Wim Derave, Professor

CONTACT

[email protected]

92646326 ext. +32

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Collaborators

  • Research Foundation Flanders

Registry information

Official study title

The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Nov 30, 2023
Registry last updated
Dec 13, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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