The Role of Genetic Factors in the Development of Idiopathic Osteoarthritis of the Knee in the Kazakh Population

Inclusion criteria

• Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;
• Representatives of the Kazakh ethnic group up to the 3rd generation;
• Hereditary history of arthrosis;
• Persons who are able and willing to provide written informed consent;

Exclusion criteria

• Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;
• Representatives of other ethnic groups;
• Representatives of the Kazakh ethnic group less than 3 generations;
• No family history of bilateral idiopathic gonarthrosis;
• Patients with an acute period of the inflammatory process (laboratory and clinical signs);
• Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
• Pregnant or lactating women;
• Tuberculosis of any localization in the active phase and in history;
• Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
• Severe and decompensated course of endocrine diseases;
• Autoimmune diseases;
• Systemic diseases;
• Oncological diseases;