The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)

To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Acute Renal Failure Acute Kidney Injury Anemia Anemia, Hemolytic Blood Platelet Disorders Chronic Disease Chronic Kidney Failure Cytopenia Disease Attributes Endothelial Dysfunction Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hematologic Diseases Hemic and Lymphatic Diseases Hemolytic-Uremic Syndrome Hemolytic-uremic Syndrome (HUS) Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Thrombocytopenia Thrombotic Microangiopathies Uremia Urogenital Diseases Urologic Diseases

Age range

2 year–20 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University Of Alabama

Birmingham, Alabama, 35233, United States

About this study

This research study is designed to study what happens to the kidneys after they have an injury. There is some evidence that even if there appears to be great improvement of kidney function, an injury can put patients at risk for long-term problems with their kidney function and increase their risk to have high blood pressure. We want to collect information from participants to help explain why this injury can cause future problems, including Chronic Kidney Disease (CKD) which may help us prevent these health problems.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children between age 2-20
Decrease in renal function by 25% or greater
Renal function has returned to normal

Exclusion criteria

History of chronic disease
Cancer
Congenital heart disease
Organ Transplantation
Liver disease
Pulmonary disease
Diabetes other primary metabolic condition
Severe neurologic impairments
Hypertension
Auto-immune
Infectious disease or renal disease
Smokers
Renal disease w/primary cause i.e. - HUS or Glomerulonephritis
severe allergies including allergy to seafood and/or iodine

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Registry information

Important dates

Study start: 2008
Primary completion: 2009
Study completion: 2009
First posted: Jul 31, 2006
Registry last updated: May 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed