The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content

Overweight but otherwise healthy men will be included in the study which is a randomized diet intervention study in a cross over design.

The study involves 2 intervention periods of 5 days each, during which the participant ingests two different types of experimental diet. Participants will in randomized order (determined by block randomization) ingest a diet with low carbohydrate and high fat content, and a diet with high carbohydrate and low fat content.

Inclusion criteria

• Healthy men being 18-50 years old.
• Overweight (BMI 25-35)
• Low to moderate physical activity level, defined as ≤ 1 weekly session of aerobic exercise.
• Non-smokers
• No use of medicine

Exclusion criteria

• Fasting blood glucose indicating overt diabetes (≥7 mmol/l)
• HbA1C >48 mmol/mol
• Fasting plasma triacylglycerol indicating dyslipidemia (≥2.2 mmol/l)
• FIB-4 score >1.45
• Contraindications for MR-scan: abdominal height exceed limitations of the MR-scanner, pacemaker or other electronic device implanted, implanted metal devices, severe claustrophobia.