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OpenTrials
Completed

NCT Number: NCT04560530

The Role of CT Chest Scan in the Pre-anesthetic Assessment of Suspected or Confirmed COVID -19 Patients

The role of CT scan of the chest in Pre-anesthetic assessment of the severity of COVID-19 and the correlations between CT measurements of the aortic and pulmonary arteries diameters and severity of pneumonia.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Security Forces Hospital

Riyadh, Saudi Arabia

About this study

Patients who were scheduled for emergency surgery during COVID-19 pandemic should have be screened for COVID pre-operatively given the prevalence f asymptomatic or mildly symptomatic cases that could be carriers to infection and possibly cause cross infection to the operating room staff especially the anesthetists who deal with the upper airway during intubation with high possibility of getting infected with SARS-COV 2 virus. Waiting respiratory tract PCR (RT-PCR) test for COVID can delay the surgery which may increase patients morbidity and mortality. RT-PCR test has limited sensitivity and specificity.

Patients who are confirmed to have COVID-19 infection (have positive RT-PCR) or patients who have possible COVID-19 infection (have symptoms but were not tested with RT-PCR) will undergo non-enhanced CT scanning of the chest (without giving IV contrast).

Chest CT scan will be interpreted by 2 Consultants radiologists with an experience of at least 10 years in their field.

The radiologists are going to be requested to comment on the lung parenchyma, describing the findings , assess the pulmonary artery, aorta diameters and the aorta:pulmonary diameters ratio will be then calculated. The degree of pneumonia severity index will then be described as well.

The radiologists will be blinded to the aim of the study.

All data will be collected and then correlation between the data sets will be statistically tested.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients scheduled for emergency surgery with symptoms suggestive of COVID-19 infection.

Exclusion criteria

  • Pregnancy.
  • Haemodynamic instability (Mean arterial blood pressure above 65 mmHg or the need for of inotropic drugs to maintain mean arterial blood pressure above 65 mmHg).
  • Active bleeding.
  • Any indication by the surgeon or the anesthesiologist to proceed for immediate surgery for the patient safety.
  • Patients refusal to do CT scanning.

Treatment and study plan

Non-enhanced CT scan of the chest

Radiation

Non-enhanced CT scan of the chest with multi-slice CT scan machine.

Primary outcomes

  1. pneumonia severity.

    Time frame: 90 days

    The pneumonia severity will be assessed by the radiologist.

  2. Aorta diameter

    Time frame: 90 days

    Aorta cross sectional diameter will be calculated by using cursor method on CT scan

  3. Pulmonary artery diameter

    Time frame: 90 days

    Pulmonary artery sectional diameter will be calculated by using cursor method on CT scan

  4. Pulmonary artery diameter TO Aorta diameter ratio

    Time frame: 90 days

    Pulmonary artery diameter TO Aorta diameter ratio will be calculated

Secondary outcomes

  1. Description of the lesions found in the CT scan

    Time frame: 90 days

    The parenchymal lesions will be described by the radiologist

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

The Use of Preoperative CT Chest Scan in the Pre-anesthetic Assessment of COVID-19

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Sep 23, 2020
Registry last updated
Sep 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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