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OpenTrials
Completed

NCT Number: NCT05747235

The Role of Computed Tomography in the Phenotyping of COPD Patients

Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease that is characterized by respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. the CT was used for classification of COPD patients into different phenotypes: phenotype A that has minimal emphysema with or without airway disease, phenotype E that has emphysema without airway disease, and finally phenotype M as a mixed form. The investigators aimed to to identify the phenotypes of COPD using radiologic data obtained by computed tomography. Moreover, this study will be designed to answer the questions about possible correlation between pulmonary function parameters and CT.

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Islam Galal Sayed

Asyut, Egypt

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All stable COPD patients that lastly confirmed to have the disease based on spirometry and past clinical history according to GOLD (2022).
  • Age above 18 years.

Exclusion criteria

  • COPD patients associated with other chest diseases as collapse
  • COPD patients associated with consolidation
  • COPD patients unable to perform spirometry

Treatment and study plan

CT chest

Radiation

All patients will undergo MSCT chest at both inspiratory and expiratory phases in supine position without any contrast media.

Primary outcomes

  1. Identifying the different phenotypes of COPD using HRCT

    Time frame: one month

    Identifying the different phenotypes of COPD using HRCT. moreover, to identify whether there is a possible correlation between CT phenotypes and FEV1, FVC or FEV1/FVC.

Sponsors and collaborators

Lead sponsor

Aswan University

Other

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Feb 28, 2023
Registry last updated
Feb 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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