The Role of Blood Perfusion in Cervical Cancer, Cervical Intraepithelial Neoplasm and Ovarian Cancer Patients

This study will elucidate the role of 3D transvaginal ultrasound in assessing (1) cervical vascularity and blood flow in patients with cervical cancer and cervical intraepithelial neoplasm, and (2) tumor vascularity and blood flow in patients with ovarian cancer.

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Key information

Conditions

Cervical Cancer Adnexal Diseases Cervical Intraepithelial Neoplasm Endocrine Gland Neoplasms Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Gonadal Disorders Neoplasms Neoplasms by Site Ovarian Cancer Ovarian Diseases Ovarian Neoplasms Precancerous Conditions Urogenital Diseases Urogenital Neoplasms Uterine Cervical Diseases Uterine Cervical Dysplasia Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms

Sex eligibility

Female

Study type

Observational

Primary location

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital,, New Taipei City, Banqiao, Taiwan

About this study

Patients and methods:

Women with cervical cancer, cervical intraepithelial neoplasm, ovarian cancer, or the control will be invited to particilate in this study.Then, 3D power Doppler Ultrasound will be performed to capture (1) the cervical volume, vascularity and blood perfusion, and (2) ovarian tumor vascularity and blood perfusion. The sonographic data will be correlated to clinical and pathological data.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions, and the correlation between hemoperfusion and prognosis":

Adult women who have had a normal cervical smear within the past three years and have no other gynecological cancers (control group).
Adult women with cervical cancer or precancerous lesions.
Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer":

Adult women suspected of having ovarian cancer, fallopian tube cancer, or peritoneal cancer before surgery.

Exclusion criteria

Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions of the cervix, and the correlation between hemoperfusion and prognosis":

Patients who cannot cooperate with vaginal 3D ultrasound scans.
Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer":

Patients who cannot cooperate with vaginal or abdominal 3D ultrasound scans.

Treatment and study plan

Doppler Ultrasound

Diagnostic Test

3D doppler ultrasound to measure VI, FI, VFI.

Primary outcomes

Vascularization-flow index

Time frame: 3 years
- Compare the vascularization-flow index values between cervical cancer, cervical intraepithelial neoplasia and the control group.
- To assess whether vascularization-flow index is a predictor of progression-free survival in women with ovarian cancer

Secondary outcomes

Vascularization index

Time frame: 3 years
- Compare the vascularization index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether vascularization index is a predictor of progression-free survival in women with ovarian cancer
Flow index

Time frame: 3 years
- Compare the flow index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether flow index is a predictor of progression-free survival in women with ovarian cancer

Sponsors and collaborators

Lead sponsor

Far Eastern Memorial Hospital

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2030
Study completion: 2030
First posted: Feb 4, 2026
Registry last updated: Feb 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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