The ROAR Study: Reactive Oxygen Species and Reproduction

This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative stress to oocyte competence as determined by embryo development outcomes. Furthermore, we will measure oxidative stress in sperm and correlate the overall oxidative stress within the couple with IVF and pregnancy outcomes of the resultant embryos.

Recruiting

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Key information

Conditions

Ovarian Aging IVF Outcome Oxidative Stress

Age range

18 year–43 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of California, San Francisco

San Francisco, California, 94158, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female age 18-43 years
Subjects planning blastocyst culture for preimplantation genetic screening (PGS) for aneuploidy.
Male partners 18 years of age or older.
Must be a registered patient at UCSF Center for Reproductive Health
Patient and partner must both be physically present on the day of retreival

Exclusion criteria

Female partner age 44 or older
Planning fresh transfer (hybrid PGS cycle)
Cleavage stage biopsy
Planning to use frozen sperm

Treatment and study plan

Oxidative stress markers

Diagnostic Test

We will measure markers of oxidative stress in the follicular fluid, semen, and blood and correlate this with IVF and reproductive outcomes

Primary outcomes

Implantation rate

Time frame: From enrollment to transfer of all embryos - can be anywhere from 8 weeks to 1 year (or sometimes longer if pregnancy is achieved)

Implantation rate of euploid embryos that result from a specific oxidative stress environment

Study contacts

Contact information is provided by the study sponsor or research team.

Elena Hoskin, BS

CONTACT

[email protected]

(415) 885-3598

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Acronym: ROAR

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Feb 17, 2025
Registry last updated: Feb 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting