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Completed

NCT Number: NCT04437459

The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test

This study aims to evaluate the reliability of a shortened fat tolerance test ("abbreviated fat tolerance test", or "AFTT") for measuring post-meal lipids in human blood. The reliability of the triglyceride results in this test are compared to the reliability of the glucose results from an oral glucose tolerance test (OGTT), a widely-used and clinically accepted metabolic test.

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Key information

Conditions

Dyslipidemias Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Lipid Metabolism Disorders Metabolic Diseases Metabolic Syndrome Nutritional and Metabolic Diseases

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Oklahoma State University

Stillwater, Oklahoma, 74078-6104, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Free of chronic disease
  • Normal (healthy) fasting glucose and triglycerides

Exclusion criteria

  • Presence of pace-maker
  • Pregnant
  • Using tobacco products
  • Using medications or dietary supplements that could modify primary outcomes

Treatment and study plan

high-fat shake

Other

Participant consumes a high-fat test shake. Blood is drawn before and 4 hours after this shake to measure triglycerides.

Pure glucose solution

Other

Participant consumes 75 grams of pure glucose. Blood is drawn before and 2 hours after this drink to measure glucose.

Primary outcomes

  1. Reliability of the Change in Triglycerides after a High-Fat Meal

    Time frame: The two fat tolerance tests are separated by 1 week.

    Participants complete two fat tolerance tests. In each test, triglycerides are measured in blood immediately before and 4 hours after consumption of a high-fat meal. The reliability/agreement in measuring the triglyceride change between the 2 tests is being determined.

  2. Reliability of the Change in Glucose after Ingestion of a Glucose Solution

    Time frame: The two glucose tolerance tests are separated by 1 week.

    Participants complete two glucose tolerance tests. In each test, glucose is measured in blood immediately before and 2 hours after consumption of a pure glucose solution. The reliability/agreement in measuring the glucose change between the 2 tests is being determined.

Sponsors and collaborators

Lead sponsor

Oklahoma State University

Other

Registry information

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Jun 18, 2020
Registry last updated
Jun 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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