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NCT Number: NCT06922071

The REMINDER4Care Program for Older Adults Supported by Residential and Daycare Facilities

Dementia incidence is rising, posing a public health challenge, but 45% of cases can be prevented by addressing modifiable risk factors. Multidomain trials show that lifestyle changes can improve cognitive function and reduce dementia risk (like the FINGER trial). The REMINDER program, a Portuguese-based dementia risk reduction protocol, was developed for community-dwelling older adults aged 55 and above. However, older adults in Residential and Daycare Facilities (RDF) have distinct needs that demand program adaptation to ensure its relevance and effectiveness. In addition, more studies are needed to evaluate the impact of multidomain interventions with older adults in RDF.

To address these challenges, the REMINDER4Care program was developed as a tailored, multidomain intervention to reduce dementia risk. It emphasizes social and cognitive engagement and advances its adaptation and evaluation in Residential and Daycare Facilities (RDF). To assess efficacy, the investigators will perform a Randomized Controlled Trial.

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Key information

Conditions

Dementia Risk Factors Cognitive Health Prevention

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Psychology and Education Sciences

Coimbra, Portugal, 3000-115

Location status: Recruiting

Location contact

Catarina L. B. Baptista, PhD Student

PRINCIPAL_INVESTIGATOR

Catarina L. B. Baptista, PhD student

CONTACT

[email protected]

+351 963 031 318

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 65 years and older
  • RDF users
  • Elementary reading and writing skills

Exclusion criteria

  • Have a clinical diagnosis of dementia and/or Mini-Mental State Examination (MMSE) scores below the cutoff for the presence of dementia (MMSE < 22-27, depending on education level)
  • Have a psychiatric or neurological condition that impairs cognition in the long term
  • Have sensory and functional deficits that compromise their participation in the neuropsychological assessment and throughout the intervention sessions

Treatment and study plan

REMINDER4Care

Other

REMINDER4Care was an adapted version of the original REMINDER program, tailored to the characteristics, needs, and interests of older adults in RDF.

The REMINDER4Care intervention includes 20 face-to-face group sessions, each approximately 60 to 75 minutes, held twice a week over ten weeks. This program aims to optimize memory, attention, executive function, and emotional regulation while promoting lifestyle habits that protect the aging brain. The sessions include brain health education, cognitive exercises, compensatory memory strategies, training for managing personally relevant goals (with goal setting), and stress management techniques (compassion-based therapies, relaxation methods, and mindfulness). Social support and emotion regulation strategies (like attention management, positive cognitive reappraisal, and reframing speech) were included to address psychosocial risk factors like stress, social isolation, and depression.

Primary outcomes

  1. Screening

    Time frame: Screening

    Participants' sociodemographic (e.g., age, marital status, education level) and clinical (presence of medical diagnosis, current medication, sensory issues, mobility deficits, substance use, and hospitalization).

  2. Screening

    Time frame: Screening

    Dementia risk was assessed using the Lifestyle for BRAin health (LIBRA) score, which ranges from -2.1 to 10.6, with higher scores indicating a greater risk of developing dementia.

  3. Cognitive status

    Time frame: Screening and 1-week and 3-months post-intervention

    Global cognition was assessed using Addenbrooke's Cognitive Examination - Revised (ACE-R), a scale with scores ranging from 0 to 100, where higher scores indicate better cognitive functioning.

  4. Mood status

    Time frame: Screening and 1-week and 3-months post-intervention

    Depressive Symptoms: Assessed using the Geriatric Depression Scale (GDS-30), a 30-item scale with scores ranging from 0 to 30, where higher scores indicate greater depressive symptoms.

  5. Cognitive status

    Time frame: Baseline and 1-week and 3-months post-intervention

    Processing Speed: Evaluated with the Symbol Search subtest of the WAIS-III, scored by correct responses within a time limit, with higher scores representing faster processing speed.

  6. Cognitive status

    Time frame: Baseline and 1-week and 3-months post-intervention

    Verbal Initiative: Measured with the Verbal Fluency Test (letters M, R, and alternate category), scored by the number of correct words produced, with higher scores indicating greater verbal initiative.

  7. Perceived social isolation and loneliness

    Time frame: Baseline and 1-week and 3-months post-intervention

    Loneliness: Measured with the UCLA Loneliness Scale (UCLA LS-3), the score was 20 to 80, with higher scores reflecting greater perceived loneliness.

  8. Perceived social network

    Time frame: Baseline and 1-week and 3-months post-intervention

    Social Networks: Evaluated using Lubben's Brief Social Network Scale (LSNS-6), scored from 0 to 30, where higher scores indicate a stronger social network.

  9. Functionality status

    Time frame: Baseline and 1-week and 3-months post-intervention

    Functional abilities: This is measured using the IAFAI (Informant Assessment of Functioning in Aging and Intellectual Disabilities).

  10. Perceived quality of life

    Time frame: Baseline and 1-week and 3-months post-intervention

    Psychological Well-Being: Assessed using the EBEP-R is a short version of the Psychological Well-Being Scale. Higher scores on the EBEP-R indicate better psychological well-being.

Study contacts

Contact information is provided by the study sponsor or research team.

Catarina L. B. Baptista, PhD Student

CONTACT

[email protected]

+351 963 031 318

Sponsors and collaborators

Lead sponsor

University of Coimbra

Other

Collaborators

  • Fundação para a Ciência e a Tecnologia

Registry information

Acronym: REMINDER4Care

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Apr 10, 2025
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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