Taipei city hospital
Taipei, Taiwan
NCT Number: NCT02101437
For acute coronary syndrome patients undergoing cardiac catheterization after stenting, we will give dual antiplatelet drugs (dual antiplatelet agents) therapy, the choice of the basis of medical criteria (clinical guidelines) routine as aspirin + clopidogrel or aspirin + ticagrelor, according to medical guidelines currently no other disposal alternative proposal (unless adverse drug tolerance or bleeding can not be administered); idea of this experiment for acute coronary syndrome or conventional cardiac catheterization after stenting, platelet miRNA expression (miR-96 , miR-200b, miR-495, miR-107) after cardiac catheterization and interventional treatment of clopidogrel or ticagrelor acceptance of platelet reactivity (PRU) correlation values (given clopidogrel or ticagrelor determined by the clinician, the patient follow-up experiment to track only and observation), aims to explore under different platelet reactivity (hyper-reactive or hypo-reactive), their differences in miRNA performance.
Looking for future studies?
Notify MeHealthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
1 under DAPT (dual antiplatelet therapy) of stable angina patients for elective stent implantation.
Exclusion criteria
1.Not suitable for the treatment of patients with DAPT. (Active peptic ulceration or bleeding) 2 patients of aspirin, clopidogrel, ticagrelor, cilostazol medication intolerance.
3 contraindications for aspirin, clopidogrel, ticagrelor, cilostazol drug usage (such as heart failure patients not suitable for use cilostazol).
miRNA within 24hr
miRNA after 1 week
miRNA after 1 month
Time frame: 7 days
miRNA-365-3p measure by Roche miRNA kits; PRP(platelet riched plasma) isolated miRNA by isolation Kit, then havest in cDNA synthesis Kit; then perform RT PCR.
.
Taipei City Hospital
Other Gov
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Published trials that share one or more normalized conditions with this study.
NCT04772495
Autoimmune Diseases, Autoimmune Diseases of the Nervous System
View Trial DetailsNCT04583085
Arterial Occlusive Diseases, Arteriosclerosis
Chennai, Tamil Nadu, India
View Trial DetailsNCT07114497
Bone Diseases, Degeneration Disc Intervertebral
Çanakkale, Turkey (Türkiye)
View Trial DetailsNCT03635255
miRNA
Taipei, Taiwan
View Trial Details