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Completed

NCT Number: NCT04945577

The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection

Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.

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Key information

Conditions

Vitamin D Deficiency Avitaminosis COVID-19 Coronaviridae Infections Coronavirus Infections Covid19 Deficiency Diseases Infections Lung Diseases Malnutrition Nidovirales Infections Nutrition Disorders Nutritional and Metabolic Diseases Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

16 year–97 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Gulcan Ozturk

Istanbul, 34752, Turkey (Türkiye)

About this study

In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months

Exclusion criteria

  • Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study

Treatment and study plan

Inflammatory Parameters

Diagnostic Test

Laboratory measurement of patient's inflammatory status in unit of % and mg/dl

25 OH Vitamin D Level

Other

Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl

Primary outcomes

  1. 25-OH vitamin D

    Time frame: 1 day

    laboratory measurement in unit of ng/ml

  2. White blood cell count

    Time frame: 1 day

    laboratory measurement in unit of x103/uL

  3. neutrophil count

    Time frame: 1 day

    laboratory measurement in unit of x103/uL

  4. neutrophil ratio

    Time frame: 1 day

    laboratory measurement in unit of %

  5. lymphocyte count

    Time frame: 1 day

    x103/uL

  6. lymphocyte ratio

    Time frame: 1 day

    laboratory measurement in unit of %

  7. platelet count

    Time frame: 1 day

    laboratory measurement in unit of x103/uL

  8. hemoglobin count

    Time frame: 1 day

    laboratory measurement in unit of g/dl

  9. C-reactive protein levels

    Time frame: 1 day

    laboratory measurement in unit of mg/dL

  10. neutrophil to lymphocyte ratio

    Time frame: 1 day

    laboratory measurement in unit of %

  11. platelet to lymphocyte ratio

    Time frame: 1 day

    laboratory measurement in unit of %

Sponsors and collaborators

Lead sponsor

Fatih Sultan Mehmet Training and Research Hospital

Other

Registry information

Official study title

The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection: A Retrospective Study

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jun 30, 2021
Registry last updated
Jun 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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