The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the the relationship between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

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Key information

Conditions

Cohort Studies Confusion Delirium Emergence Delirium Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

65 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Chinese PLA General Hospital

Beijing, Beijing Municipality, China

About this study

This is a retrospective cohort study using prospective data from a multicenter database. 8000 elderly patients undergoing elective non-cardiac or non-neurosurgical surgery were included in this study. The Generalized Anxiety Disorder Scale (GAD-7) was used to measure preoperative anxiety symptoms. The confusion assessment method (3D-CAM) was used to assess postoperative delirium in elderly patients undergoing non-cardiac surgery. If the patient is discharged, follow up by phone or email. Binary logistic regression analysis and propensity score matching (PSM) and subgroup analysis were used to analyze the data.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

elderly patients (age ≥ 65 years)
non-cardiac surgery, non-neurosurgical surgery

Exclusion criteria

History of neurological or psychiatric disorders or use of neuropsychiatric drugs;
Impaired cognitive function or inability to cooperate with preoperative follow-up;
Sent to ICU after surgery;
Deletional delirium outcome;
Baseline missing >5%

Treatment and study plan

Primary outcomes

Postoperative delirium

Time frame: within 7 days after surgery

The incidence of postoperative delirium was assessed by a 3-minute diagnostic interview in the surgical ward (3D-CAM).

Sponsors and collaborators

Lead sponsor

Chinese PLA General Hospital

Other

Collaborators

Beijing Anzhen Hospital
Beijing Tiantan Hospital
Central South University
China-Japan Friendship Hospital
First Affiliated Hospital of Guangxi Medical University
First Affiliated Hospital of Xinjiang Medical University
Fudan University
Peking University First Hospital
Peking University People's Hospital
Shanghai Zhongshan Hospital
Sun Yat-sen University
Taihe Hospital
The Affiliated Hospital Of Guizhou Medical University
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Xiangya Hospital of Central South University
Zhejiang Provincial People's Hospital
Zhejiang University

Registry information

Official study title

The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Mar 6, 2025
Registry last updated: Mar 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed