The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation

To explore the relationship between Microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.

Inclusion criteria

• Histopathology or cytopathology proven gastric cancer;
• Operable advanced gastric cancer patients: primary lesions can be completely excision, no distant metastasis;
• Postoperative patients who can tolerate 5-FU based (5-FU，S-1 or Capecitabine) adjuvant chemotherapy;
• Life expectancy of at least 6 months;
• ECOG（Eastern Cooperative Oncology Group ） score 0-1;
• Age: 18~80 years old;
• Normal hemodynamic indices before the recruitment (including blood cell count and liver/kidney function).

• For example: WBC（White blood cell count ）>4.0×109/L; NEU（Neutrophils）>1.5×109/L; PLT（Platelet）>100×109/L;
• Roughly normal cardiopulmonary function: No coronary heart disease, myocardial infarction, pulmonary heart disease, refractory hypertension;
• Not concomitant with other uncontrollable benign diseases before the recruitment;

• Voluntarily signed the informed consent.

Exclusion criteria

• Advanced gastric cancer patients with distant metastasis and inoperable ;
• Patients who cannot tolerate 5-FU based adjuvant chemotherapy;
• Pregnant or lactating women;
• Patients who have no desire to participate in the study.