The Relationship Between Early Motor Repertoire Quality and Later-term Motor Function in Children With CP

Cerebral palsy (CP) is a group of disorders attributed to non-progressive disorders occurring in the developing fetal, infantile brain, affecting posture, movement development, and activity limitations. It occurs in approximately 2 to 2.5 per 1,000 live births. The prognosis for gross motor function among children with CP is extremely variable. This variability poses a significant challenge to scientific definitions of motor function for clinicians who regularly deal with practical issues such as examination, prognosis, intervention planning, and outcome assessment in children with CP. Observing the general quality of movement of preterm or term babies can be used to identify babies at risk of developing neurological disorders and can provide information about possible future motor function.

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Key information

Conditions

Cerebral Palsy Brain Damage, Chronic Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

3 month–5 month

Sex eligibility

All sexes

Study type

Observational

Primary location

Türkiye Spastik Çocuklar Vakfı

Istanbul, Ataşehir, 34750, Turkey (Türkiye)

About this study

They frequently use the 66-item Gross Motor Function Measurement (GMFM-66) to evaluate gross functions and the Gross Motor Function Classification System (GMFCS) to classify gross motor functions. It is important to use the data obtained from these methods to assist in examination, prognosis, intervention planning and outcome evaluation for children with CP. In addition, the Motor Optimality Score (MOS), which is based on observing the quantity and quality of movement patterns, is used. When we look at the literature, there are very few studies comparing the amount and quality of the motor repertoire obtained using the early motor optimality score with the motor functions in the later period. Therefore, in this study, in addition to evaluating general movements in early infancy (3-5 months), it is aimed to predict the motor function in the future by evaluating the quality and amount of motor repertoire (motor optimality score, MOS) (movement and posture of the baby).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Children with a diagnosis of Cerebral Palsy
Children who applied to the Turkish Spastic Children Foundation between 2011-2023
Availability of Prechtl General Movements Assessment recordings obtained between 10-20 weeks post-term age
Availability of GMFM-66 assessment data

Exclusion criteria

Lack of parental or legal guardian consent
Presence of additional diagnoses affecting motor assessment
Cases where GMFM-66 evaluation was not applicable
Incomplete clinical records

Treatment and study plan

Primary outcomes

Motor Optimality Score (MOS)

Time frame: 3 months

Motor optimality score (MOS) have 5 categories to the score. These are fidgety movements (max 12 points), repertoire of co-existent other movements (max 4 points), quality of other movements (max 4 points), posture (max 4 points) and movement character (max 4 points). The category scores are added to a max of 28 points.
Gross Motor Function Measurement (GMFM-66)

Time frame: 3 months

The Gross Motor Function Measure (GMFM) is a tool that has been developed to assess change in gross motor function in children with cerebral palsy aged 5 months to 16 years of age.1 The GMFM measures 'activity' as defined within the Interna- tional Classification of Functioning, Disability and Health.2 To administer the GMFM, a trained therapist observes the child completing a number of gross motor tasks in a standardised environment, and the child's best ability is measured.

Sponsors and collaborators

Lead sponsor

Uskudar University

Other

Registry information

Important dates

Study start: 2023
Primary completion: 2024
Study completion: 2024
First posted: Mar 27, 2026
Registry last updated: Mar 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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