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NCT Number: NCT03677635

The Relationship Between Autobiographical Memory and Motivation

People with a diagnosis of psychosis often experience low motivation and pleasure when thinking about doing future activities. This leads, quite understandably, to doing fewer activities they used to enjoy and not taking up opportunities to do new activities. One model suggests that this may be partly due to difficulties using memories of previous events to help boost motivation and anticipation before a future activity. Research shows that people with psychosis may recall previous events in less detail. These memories therefore may not be as helpful as they could be for motivation. This study will investigate this by asking people with experience of psychosis and low motivation who are seen by a care team in South London and Maudsley NHS Trust to attend two research sessions. In the first session the participants will be asked to recall memories of events from their lives and the researcher will assess how detailed the memories are and how much the participant refers to the past and future. Alongside this task the participants will also be asked to complete measures of symptoms such as low pleasure and motivation as well as a measure of depression. These will be used to find out if the detail and specificity of the memories are related to these symptoms in people with psychosis. The second half of the study will then investigate whether additional prompts to support positive memory retrieval can increase the specificity of this and subsequently improve mood, motivation and self-belief. Participants will be randomised to one of two groups. The clinical group will be guided through their memory recall using prompts and a control group will be asked to recall positive memories without prompts. If the investigators show that supporting memory recall is beneficial then memories for past events may be an important target for future therapies.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Psychiatry, Psychology & Neuroscience, KCL, London, United Kingdom

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • A diagnosis of non-affective psychosis (as determined by medical records).
  • Above 18yrs old.
  • A score of at least 18 on the Clinical Assessment Interview for Negative Symptoms.
  • A sufficient command of the English language to engage with the research materials

Exclusion criteria

  • Lack of capacity to provide informed consent.
  • Primary diagnosis of intellectual disability, head injury, substance misuse or known organic cause of psychosis

Treatment and study plan

Guided Autobiographical Memory Recall

Behavioral

Participants are asked to recall positive autobiographical memories with the assistance of prompts to promote specificity, generalisability and links to the future. The participants will also view a 5min psychoeducation video on the subject of memory specificity and motivation.

Primary outcomes

  1. Post-Intervention Motivation Score

    Time frame: Immediately after completing the intervention

    A rating on a visual analogue scale assessing motivation to repeat the same activity recalled in the future. The scale is rated from 0-100 and a higher score indicated better outcome.

Secondary outcomes

  1. Post-Intervention Anticipatory Pleasure

    Time frame: Immediately after completing the intervention

    A rating on a visual analogue scale assessing how pleasant that activity is anticipated to be if repeated. The scale is rated from 0-100 and a higher score indicated better outcome.

Sponsors and collaborators

Lead sponsor

King's College London

Other

Registry information

Official study title

Is There a Relationship Between Memory for Past Events and Motivation for Future Activities?

Important dates

Study start
2017
Primary completion
2018
Study completion
2020
First posted
Sep 19, 2018
Registry last updated
Jul 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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