Kirsehir Ahi Evran University
Kırşehir, Turkey (Türkiye)
Location status: Recruiting
Recruiting
NCT Number: NCT06739369
The Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Ankylosing Spondylitis
The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–85 year
Sex eligibility
All sexes
Study type
Observational
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Diagnosis of ankylosing spondylitis according to ASAS diagnostic criteria
- Being aged 18-65
- Stable medication use for at least 3 months
- Voluntary participation in the study
Exclusion criteria
- Having uncontrolled cardiopulmonary disease
- Being pregnant
- Having undergone recent surgery
- Presence of malignancy
- Failure to perform to assessments
Treatment and study plan
Primary outcomes
-
Arterial stiffness
Time frame: 1st day
It will be evaluated with brachial pulse waves.
-
Respiratory muscle strength
Time frame: 1st day
Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) will be measured using a portable mouth pressure device.
-
Respiratory muscle endurance
Time frame: 1st day
This will be evaluated with increased workload testing.
-
Exercise capacity
Time frame: 1st day
Exercise capacity will be assessed with 6 minute walk test.
-
Peripheral muscle strength
Time frame: 1st day
Hand grip strength will be assessed with a grip dynamometer.
-
Muscle function
Time frame: 1st day
It will be evaluated with one-minute sit to stand test
Secondary outcomes
-
Physical activity
Time frame: 1st day
Physical activity level will be evaluated using International Physical Activity Questionnaire-Short form
-
Forced vital capacity
Time frame: 1st day
Forced vital capacity (FVC) will be assessed using spirometry.
-
Forced expiratory volume in one second
Time frame: 1st day
Forced expiratory volume in one second (FEV1) will be assessed using spirometry.
-
Forced expiratory volume in one second/forced vital capacity ratio
Time frame: 1st day
Forced expiratory volume in one second/forced vital capacity ratio will be assessed using spirometry.
-
Peak expiratory flow
Time frame: 1st day
Peak expiratory flow (PEF) will be assessed using spirometry.
-
Forced mid-expiratory flow
Time frame: 1st day
Forced mid-expiratory flow (FEF25-75) will be assessed using spirometry.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Kirsehir Ahi Evran Universitesi
Other
Registry information
Official study title
Investigation of the Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Patients With Ankylosing Spondylitis
Important dates
- Study start
- 2025
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Dec 18, 2024
- Registry last updated
- Aug 12, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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