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Completed

NCT Number: NCT05429242

The Relation Between Placental Volume at the 1st Trimester and Perinatal Prognosis

It has been known for years that placental transport and endocrine and metabolic functions of the placenta are the main determinants of fetal nutrition and homeostasis. And placental capacity is roughly related to the weight of this organ. It has long been understood that placental weight at birth is also positively associated with birth weight. Since the 1970s, it has been possible to assess the size of the placenta in early pregnancy using two-dimensional (2D) ultrasonography (USG). Since then, it has been estimated that placental size is associated with fetal development. However, the difficulty in defining the required sonographic planes due to the technology of that time-limited the usefulness of this technique. As studies on this subject increase with the development of technology, it has now been shown that low placental volume at 11-13 weeks is associated with babies small for gestational age (SGA), fetal growth restriction, and preeclampsia. Pregnancy complications place a severe burden on the health system. Detection of these complications in the early period will prevent maternal and fetal mortality and morbidity. A relationship that predicts obstetric, fetal, and perinatal risks with placental thickness and width measurement with USG, a non-invasive method, in an early period such as the 1st trimester, will enable a proactive approach to complications. In our study, the investigators plan to present the perinatal results they obtained rather than investigating a specific relationship. The investigators think that the results of their study will make a profound contribution to the literature.

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Key information

Conditions

Pregnancy Complications Female Urogenital Diseases and Pregnancy Complications Maternal-Fetal Relations Perinatal Problems Urogenital Diseases

Age range

18 year–50 year

Sex eligibility

Female

Study type

Observational

Primary location

Siirt Üniversity Medical Faculty

Siirt, 56000, Turkey (Türkiye)

About this study

This study aims to determine the relationship between the calculated placental volume in the 1st trimester and poor perinatal outcomes. For this purpose, approximately 360 pregnant women, who were followed up in Siirt Training and Research Hospital between June 2022 and June 2023 and were in their first trimester of pregnancy, will be included in the study. The pregnant woman's age, pregnancy history, and medical history will be recorded. The patient's gestational week, placental volume, and location will be recorded during the examination. All participants will be followed up until delivery. During delivery, gestational week, delivery type, fetal weight, APGAR score, baby gender, and pregnancy outcomes, preeclampsia, Gestational Diabetes, Gestational Hypertensive diseases, Premature rupture of membranes, preterm labor, oligohydramnios, polyhydramnios, presentation anomaly, Intrauterine death, Perinatal fetal disorders such as distress, intrauterine growth retardation, preeclampsia, placental abruption, placental invasion anomaly, placental implantation anomalies, postmaturity will be recorded. In the light of the information gathered, the relationship between placental volume in the 1st trimester and perinatal prognosis will be determined.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • >18 years of age
  • 1.st trimester pregnancy

Exclusion criteria

  • history of chronic hypertension
  • history of pre gestational diabetes
  • history of chronic diseases
  • excessive consumption of alcohol
  • smoking pregnants
  • kidney disorders

Treatment and study plan

Ultrasonographic examination

Other

Measurement of placental volume at the first trimester of pregnancy by using ultrasound.

Primary outcomes

  1. Placental thickness in millimetres and pregnancy outcomes

    Time frame: From the 1.st trimester of pregnancy up to the first month after birth ( the perinatal period,(( about 7 months ))

    The relationship between placental volume in the 1st trimester and perinatal prognosis will be tried to be determined.

  2. Pregnancy outcomes

    Time frame: Pregnancy Week at the time of birth from the first three -month period of pregnancy (about 7 months)

    Gestational age in weeks during delivery

  3. Pregnancy outcomes

    Time frame: Fetal weight at the time of birth from the first three -month period of pregnancy (about 7 months)

    Fetal weight in grams

  4. Pregnancy outcomes

    Time frame: At the first minute and 5th minute after delivery

    APGAR scores in numerical values

Sponsors and collaborators

Lead sponsor

Siirt University

Other

Registry information

Official study title

Placental Thickness and Pregnancy Outcomes

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jun 23, 2022
Registry last updated
Apr 25, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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