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NCT Number: NCT03355729

The Quebec Family Study (QFS): Role of Genetic Factors in Obesity and Its Related Risk Factors and Diseases

The Quebec Family Study (QFS) is an observational study that was planned to investigate the role of genetic factors in physical fitness, body composition, risk factors for common disease and health-related behaviour.

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Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Physical Fitness Signs and Symptoms

Age range

10 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The Quebec Family Study was an observational study with three cycles of data collection between 1978 and 1992. During the first cycle of data collection (Phase 1: 1978-1982), a total of 1,650 subjects from 375 families were recruited. During the second cycle (Phase 2: 1989-1997), 385 subjects from 105 phase 1 families were retested and an additional 372 subject from 74 families were recruited. During the third cycle (Phase 3: 1998-2002), 204 subjects from phase 1 were tested a third time, 113 subjects from phase 2 were tested a second time and 194 new subjects from 44 families were recruited.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age over 10 years

Exclusion criteria

  • Not applicable

Treatment and study plan

Primary outcomes

  1. Body composition

    Time frame: Through study completion, an average of 24 years

    Body composition as assessed by underwater weighing

  2. Body mass index (kg/m^2)

    Time frame: Through study completion, an average of 24 years

    Body mass index assessed from height and weight

  3. Abdominal fat

    Time frame: Through study completion, an average of 24 years

    Abdominal fat as assessed by commuted tomography

  4. Waist and hip circumferences (cm)

    Time frame: Through study completion, an average of 24 years

    Waist and hip circumferences (cm)

Secondary outcomes

  1. Caloric intake

    Time frame: Through study completion, an average of 24 years

    Total caloric intake and macronutrient intake using a 3-day dietary record

  2. Eating behaviour

    Time frame: Through study completion, an average of 24 years

    Eating behaviour assessed using the Three-Factor Eating questionnaire

  3. Energy expenditure

    Time frame: Through study completion, an average of 24 years

    Oxygen consumption at rest and during exercise

  4. Physical activity level

    Time frame: Through study completion, an average of 24 years

    Physical activity level assessed by questionnaire

  5. Blood pressure (mm Hg)

    Time frame: Through study completion, an average of 24 years

    Systolic and diastolic blood pressure

  6. Plasma lipid levels (mmol/L)

    Time frame: Through study completion, an average of 24 years

    Fasting levels of triglycerides, LDL-cholesterol and HDL-cholesterol in mmo/L

  7. Glucose levels (mmol/L)

    Time frame: Through study completion, an average of 24 years

    Plasma glucose levels in a fasting state and following an oral glucose tolerance test, inflammatory markers.

    Plasma glucose levels in a fasting state and during an oral glucose tolerance test

  8. Insulin levels (pmol/L)

    Time frame: Through study completion, an average of 24 years

    Plasma insulin levels in a fasting state and following an oral glucose tolerance test.

  9. C-reactive protein (CRP in mg/ml)

    Time frame: Through study completion, an average of 24 years

    C-reactive protein (CRP in mg/ml)

  10. Adiponectin levels (in micrograms/ml)

    Time frame: Through study completion, an average of 24 years

    Adiponectin levels (in micrograms/ml)

  11. Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml

    Time frame: Through study completion, an average of 24 years

    Interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF-alpha) in pg/ml

  12. Smoking habits (nb of cigarettes per day)

    Time frame: Through study completion, an average of 24 years

    Smoking habits (nb of cigarettes per day)

  13. Sleeping (hours/day)

    Time frame: Through study completion, an average of 24 years

    Sleeping (hours/day)

  14. Alcohol consumption

    Time frame: Through study completion, an average of 24 years

    Alcohol consumption (nb of drinks per week)

Sponsors and collaborators

Lead sponsor

Louis Pérusse

Other

Collaborators

  • Canadian Institutes of Health Research (CIHR)

Registry information

Official study title

The Quebec Family Study: an Observational Study Aimed at Investigating the Role of Genetic Factors in Physical Fitness, Obesity and Risk Factors for Common Diseases and Health-related Behaviours

Acronym: QFS

Important dates

Study start
1978
Primary completion
2002
Study completion
2002
First posted
Nov 28, 2017
Registry last updated
Nov 28, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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