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Completed

NCT Number: NCT04712162

The Quality of Recovery After General Anesthesia With Desflurane and Sevoflurane in Endoscopic Ureteral Lithotripsy

The good quality of recovery after general anesthesia is one of goals for short procedures and ambulatory surgeries. The study's objective was to compare the quality of recovery after general anesthesia with desflurane and sevoflurane with laryngeal mask airway for endoscopic ureteral lithotripsy.

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Key information

Conditions

Anesthesia

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Anesthesiology Department of Gia Dinh People Hospital

Ho Chi Minh City, 700000, Vietnam

About this study

This is a randomized controlled trial. There were 60 cases of endoscopic ureteral lithotripsy under general anesthesia with laryngeal mask airway were enrolled. All cases were randomly divided into two group (desflurane or sevoflurane). Each group had 30 cases. Primary outcome was time to awakening. Secondary outcomes were time to wash-out of volatile anesthetics, time to extubation, irritation after awakening, and modified Aldrete score.

Statistical analysis was performed by using Kaplan-Meieir curve and log-rank test for time to adequate depth of anesthesia and time to awakening; t-test for time to wash-out of volatile anesthetics; chi-square test for depth of anesthesia by PRST score, irritation after awakening and Aldrete score; Fisher test for adverse effects of volatile anesthetics.

The research was approved by Gia Dinh People Hospital ethics committee

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All eligible subjects who underwent endoscopic ureteral lithotripsy under general anesthesia
  • ASA I and II

Exclusion criteria

  • Contraindication to laryngeal mask airway.
  • Indication for conversion to tracheal intubation during surgery.
  • History of malignant hyperthermia.
  • Pregnancy.
  • Obese (BMI >25 kg/m2).
  • Substances abuse.

Treatment and study plan

other

Other

Compare time to awakening and quality of recovery after general anesthesia between two groups.

Primary outcomes

  1. Time to awakening

    Time frame: After stopping volatile anesthetics to patient awakening, up to 30 minutes.

    Time required for awakening

Secondary outcomes

  1. Time to wash-out of volatile anesthetics

    Time frame: After stopping volatile anesthetics to complete wash-out of volatile anesthetics, up to 30 minutes

    Time required for washing out volatile anesthetics

  2. Time to extubation

    Time frame: After stopping volatile anesthetics to readiness for extubation, up to 30 minutes

    Time required for successful extubation.

  3. Irritation after awakening

    Time frame: After awakening to eligible discharge, up to 2 hours.

    Aono score >2

  4. Adverse effects of volatile anesthetics

    Time frame: After providing volatile anesthetics until they were stopped, up to 90 minutes

    Hypotension, cough, nausea and vomitting.

Sponsors and collaborators

Lead sponsor

Gia Dinh People Hospital

Other

Registry information

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Jan 15, 2021
Registry last updated
Jan 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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