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Completed

NCT Number: NCT05906693

The Quality of Life in Individuals With Parkinson's Disease

This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease. The differences between Parkinson's Disease Quality of Life Questionnaire, Nine-Hole Peg Test, grip and pinch strength values in the individuals with and without tremor in the study were investigated.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Dyskinesias Functionality Movement Disorders Nervous System Diseases Neurodegenerative Diseases Neurologic Manifestations Parkinsonian Disorders Pathological Conditions, Signs and Symptoms Signs and Symptoms Synucleinopathies Tremor

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Pamukkale University

Denizli, Pamukkale, 20190, Turkey (Türkiye)

About this study

Evaluating the relationship between Quality of Life and tremor is needed to determine the best physiotherapy and rehabilitation approaches for individuals with Parkinson's Disease. This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease. Fifty-two individuals with Parkinson's Disease participated in the study. Quality of Life, tremor amplitude, upper limb functionality, grip and pinch strength were evaluated. The relationship of quality of life with tremor severity and upper limb functionality was examined in individuals with Parkinson's Disease. The results of individuals with and without tremor were compared.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Definite diagnosis of idiopathic Parkinson Disease
  • Age between 40 and 80 years
  • Being literate
  • Having a grade between 1-4 from the Modified Hoehn and Yahr Scale
  • Having a score lower than 11 in Hospital Anxiety and Depression Scale

Exclusion criteria

  • Who were with any other neurologic or orthopedic or rheumatologic disease affecting the upper extremity
  • Using antidepressants
  • Having vision loss
  • Deep brain stimulation

Treatment and study plan

Quality of life

Other

Parkinson's Disease Quality of Life Questionnaire (PDQ-39)

Upper limb functionality

Other

Nine-Hole Peg Test

Grip and pinch strength

Other

Dynamometer

Tremor amplitude

Other

Electromyography

Depression and anxiety levels

Other

Hospital Anxiety and Depression Scale

Clinical manifestations

Other

The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale

Primary outcomes

  1. Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale

    Time frame: 1 year

    The Movement Disorder Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale. Used for the evaluation of clinical manifestations of Parkinson's disease. The scale consists of 4 subscales: the first part is Non-Motor Aspects of Experiences of Daily Living (13), the second part is Motor Aspects of Experiences of Daily Living (13), the third part is Motor Examination (33), and the fourth part is Motor Complications (6). The total number of items in the scale is 65. The minimum score is 0. The maximum MDS-UPDRS score is higher, given the additional items and scores for each body area, with a maximum score of 272. Higher scores indicate greater impact of Parkinson Disease symptoms.

  2. Hospital Anxiety and Depression Scale

    Time frame: 1 year

    The Hospital Anxiety and Depression Scale aims to measure symptoms of anxiety and depression and consists of 14 items, seven items for the anxiety subscale (Hospital Anxiety and Depression Scale Anxiety) and seven for the depression subscale (Hospital Anxiety and Depression Scale Depression). Each item is scored on a response-scale with four alternatives ranging between 0 and 3. After adjusting for six items that are reversed scored, all responses are summed to obtain the two subscales. Both depression and anxiety subheadings are scored between 0 and 21. Higher scores indicate greater levels of anxiety or depression. Cut-off scores are 8-10 for doubtful cases and ≥11 for definite cases.

  3. Parkinson's Disease Quality of Life Questionnaire (PDQ-39)

    Time frame: 1 year

    Used to assess the quality of life of Parkinson's patients

  4. Electromyography

    Time frame: 1 year

    Used to assess the tremor amplitude of Parkinson's patients

  5. Nine-Hole Peg Test

    Time frame: 1 year

    Used to assess the upper limb functionality of Parkinson's patients

  6. Dynamometer

    Time frame: 1 year

    Used to assess the grip and pinch strength of Parkinson's patients

Sponsors and collaborators

Lead sponsor

Pamukkale University

Other

Registry information

Official study title

A Cross-sectional Study - The Quality of Life in Individuals With Parkinson's Disease: Is it Related to Functionality and Tremor Severity?

Important dates

Study start
2019
Primary completion
2020
Study completion
2021
First posted
Jun 18, 2023
Registry last updated
Jun 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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