The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease

Left ventricular ejection fraction, LVEF will be reported in percentage (%) and obtained using Simpson's biplane method from 2D echocardiography.

Left ventricular ejection fraction, LVEF will be reported in percentage (%) and obtained using 3D echocardiography

Measured from blood samples and reported as fold change

Levels of HS-CRP mg/L

Levels of CK-MB is reported in µg/L

Levels of Troponin T is reported in ng/L

Levels of Troponin I is reported in ng/L

LV EDV in milliliters (mL) will be normalized against body surface area (BSA) in m^2 to report LV EDV normalized by BSA in mL/m^2.

RV EDV in mL will be normalized against body surface area (BSA) in m^2 to report RV EDV normalized by BSA in mL/m^2.

LV ESV in mL will be normalized against body surface area (BSA) in m^2 to report LV ESV normalized by BSA in mL/m^2.

RV ESV in mL will be normalized against body surface area (BSA) in m^2 to report RV ESV normalized by BSA in mL/m^2.

Left ventricular mass in grams (g) will be normalized against BSA in m^2 and reported as g/m ^2

Left ventricular septal thickness, left ventricular posterior wall thickness and right ventricular wall thickness will be reported in centimeters (cm)

Fractional shortening will be reported as a percentage (%)

GLS(%) = (MLs - MLd)/MLd, where MLs is myocardial length at end-systole and MLd is the myocardial length at end-diastole. GLS will be reported in precentage (%)

TAPSE will be reported in millimeters (mm)

MPI is a unitless index derived from the sum of the isovolumic relaxation time (IVRT) and the isovolumic contraction time (IVCT) in milliseconds (ms) divided by the ejection time interval in (ms).

Mitral E/A ratio is derived from the ratio of the E wave velocity to the A wave velocity

peak E velocity is reported in cm/s

E wave deceleration time is reported in milliseconds (ms)

The E/e' ratio is derived from the E wave velocity to the e' velocity

Septal e' and lateral e' velocities are reported as cm/s

LAVI is reported in mL/m^2 and is the volume (mL) of the left atrium indexed against the BSA in m^2.

TRpV is reported in m/s

S wave velocity is the peak systolic velocity of the tricuspid annulus and is reported in cm/s

Indexed LV stroke volume and Indexed RV stroke volume will be reported in mL/m^2 by by indexing the volumes (mL) to BSA (m^2)

Levels of NT-proBNP from blood samples will be reported in ng/L

Levels of IGF1 from blood samples will be reported in nmol/L

Levels of ANP from blood samples will be reported in pg/mL

Levels of BDNF from blood samples will be reported in ng/mL

Levels of Tumor Necrosis Factor alpha from blood samples will be reported in pg/mL

Levels of Transforming Growth Factor Beta from blood samples will be reported in ng/mL

Levels of cardiac Myosin-Binding Protein C from blood samples will be reported in ng/L

Interleukin levels from blood sample will be reported as pg/mL

native myocardial T1 relaxation time is reported in milliseconds (ms)

Indexed LV and RV end-diastolic, end-systolic and stroke volumes will be reported in mL/m^2, by indexing the volumes (mL) to BSA (m^2)

Indexed LV mass will be reported in g/m^2 by indexing mass (g) to BSA (m^2)

LVEF will be reported in percent (%)

corrected QT interval will be reported in milliseconds (ms)

Number of participants with an abnormal ECG will be reported in %

Number of participants with abnormal liver function will be reported as %

Number of participants with abnormal kidney function will be reported as %

Number of participants with abnormal thyroid function will be reported as %

Number of participants with low Vitamin D levels will be reported as %

Extraction of information from the cardiovascular disease registry and deaths registry between 10 - 15 years from the start of the study to determine incidence of cardiovascular disease outcomes for the study cohort

Triglyceride will be reported in mmol/L

HDL-cholesterol levels will be reported in mmol/L

LDL-cholesterol levels will be reported in mmol/L

Fasting glucose levels will be reported in mmol/L

HbA1C will be reported in mmol/mol

Heart rate measured on 12 lead ECG will be reported in beats per minute.

Systolic Blood Pressure will be reported as mmHg

Diastolic Blood Pressure will be reported as mmHg

Lipoprotein a levels will be reported in mg/L

Magnesium levels will be reported as mmol/L

Calcium levels will be reported as mmol/L

Sodium levels will be reported as mmol/L

Potassium levels will be reported as mmol/L

The AUDIT-C is a validated 3-item questionnaire for identification of alcohol misuse. Each item has 5 possible responses, each scored from 0 to 4 points. Possible scores range from 0 to 12. The score cut-off for alcohol misuse is 4 points in men and 3 points in women

The average length of inpatient stays will be reported as number of days and derived from the total number of days spent admitted over the total number of admissions.

Number of hospital admissions

CGI for severity is a validated scale used to assess psychiatric illness severity by a clinician. Possible scores range from 1 (Normal, not at all ill) to 7 (Among the most extremely ill patients)

PANSS/SCI-PANSS are validated clinician administered scale used to measure symptom severity in schizophrenia and consists of 30 items divided into 3 subscales: Positive Scale, Negative Scale and the General Pathology Scale. Each subscale can be scored from 1 (absent) to 7 (extreme). Possible scores for the Positive and Negative scales range from 7 - 49, and for the General Psychopathology Scale range from 16 - 112. The further developed SCI-PANSS (structured clinical interview - for the Positive and Negative Syndrome Scale).

Duration of schizophrenia as determined from self reported year of first episode of diagnosis/ or from date of diagnosis

The length of treatment with an antipsychotic medication will be reported in years

Antipsychotic dosages will also be converted to daily equivalent dosage of chlorpromazine for comparison across different medication will be reported in mg/day

Number of participants who smoke will be reported in percent (%)

Waist Hip measurements will be reported as a ratio

Body Mass Index, BMI will be derived from participants weight and height and reported as kg/m^2

Body fat percent from body composition analysis will be reported in %

Baseline physical activity measured using the International Physical Activity Questionnaire (IPAQ) The IPAQ is validated in schizophrenia populations and the IPAQ has been validated in Norwegian populations. It is a self reported scoring system assessing physical activity over the last seven days. Physical activity can be then represented in minutes/week or MET-minutes/week.

Body muscle mass will be reported in kg

Smoking will be quantified and reported as pack/years

Age of participant will be reported in years

Gender of participant will be reported as male or female