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NCT Number: NCT06982248

The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Periodontal Pocket Mouth Diseases Periodontal Diseases Periodontitis Stomatognathic Diseases

Age range

25 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Faculty of Dentistry, Mansoura University

Aga, Egypt

About this study

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients not having systemic diseases.the 2ry aim of study to estimate the neacular factor kabba B level in gingival crevicular fluids.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients of both sexes with an age ranging between 25 and 55 years will be included in the study. Patients diagnosed as having periodontitis based on clinical and radiographic examinations will be included

Exclusion criteria

  • Insulin dependent diabetes
  • Thyroid disease
  • Patients with sensitivity to the medication used in the study
  • patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study will be excluded from the study.
  • Additionally, patients with systemic diseases, smokers, pregnant and lactating patients, and patients not compliant with oral hygiene procedures will also be excluded

Treatment and study plan

NSP and chitosan nanoparticles gel loaded by quercetin

Drug

NSP and chitosan nanoparticles gel loaded by quercetin

NSP and chitosan nanoparticles gel

Drug

NSP and chitosan nanoparticles gel

Scaling and root planning

Procedure

NSPT

Primary outcomes

  1. assessment clinical attachment level by UNC 15 periodontal probe

    Time frame: 12 weeks

Secondary outcomes

  1. assessment of the gingival crevicular levels of NF-κB by Elisa kit

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Efficacy of Quercetin Loaded on Chitosan Nanoparticles Gel as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis: Randomized Controlled Clinical Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
May 21, 2025
Registry last updated
May 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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