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OpenTrials
Completed

NCT Number: NCT05093101

The Prognostic Value of Serum Biomarkers in Osteosarcoma

Observational retrospective cohort study using laboratory data of blood tests prior to surgical and chemotherapy treatment and other histologic, clinical, and instrumental data related to patient history from digitized medical records and analysis of the same as predictors of outcomes.

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Key information

Conditions

Osteosarcoma Neoplasms Neoplasms by Histologic Type Neoplasms, Bone Tissue Neoplasms, Connective Tissue Neoplasms, Connective and Soft Tissue Sarcoma

Age range

2 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

IRCCS Itituto Ortopedico Rizzoli

Bologna, BO, 40136, Italy

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Osteosarcoma diagnosed at the Pathological Anatomy of the Rizzoli Orthopaedic Institute in Bologna;
  • Minimum 2-year follow-up period;
  • Medical records, complete blood work and instrumental examinations, regular follow-up;
  • Patients with age ≥ 2 years;

Exclusion criteria

  • Patients with osteosarcoma who have received medical treatment (surgery, radiotherapy or chemotherapy) in other hospitals prior to admission to our Institute

Treatment and study plan

case series review of clinical data

Other

Extraction of pre-surgical and chemotherapy blood test laboratory data and clinical and instrumental data related to patient history from digitized medical records and analysis

Primary outcomes

  1. Evaluation of 5-year survival

    Time frame: 5 years

    Evaluation of 5-year survival in relation to histologic, laboratory, clinical, and instrumental prognostic factors

Secondary outcomes

  1. Evaluation of the rate of local recurrence

    Time frame: 5 years

    Evaluation of the rate of local recurrence and distant metastasis in relation to histological, laboratory, clinical, and instrumental prognostic factors.

Sponsors and collaborators

Lead sponsor

Istituto Ortopedico Rizzoli

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Oct 26, 2021
Registry last updated
Apr 5, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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