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Completed

NCT Number: NCT06193109

The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock

This study sought to evaluate the association of right ventricular systolic dysfunction and 28-day in-hospital mortality in patients with sepsis and septic shock. Prospective cohort study of adult patients admitted at Burapha university hospital from October 1, 2022 through June 30, 2023 for sepsis and septic shock, who had an echocardiogram within 72 hours after admission for evaluating right ventricular systolic function. Right ventricular systolic dysfunction was defned by the American Society of Echocardiography criteria. Outcomes included 28-day in-hospital mortality, maximal blood lactate, length of intensive care unit(ICU) stay and duration of mechanical ventilation.

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Key information

Conditions

Sepsis and Septic Shock Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Burapha University Hospital

Muang Chonburi, Changwat Chon Buri, 20131, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged 18 years or older
  • diagnosed with sepsis or septic shock according to Sepsis-3 criteria
  • received an echocardiogram within 72 hours after admission

Exclusion criteria

  • prior diagnosis of pulmonary hypertension,
  • cor-pulmonale,
  • significant valvular heart disease,
  • acute coronary syndrome,
  • aortic dissection,
  • heart failure
  • inability to follow up within 28 days

Treatment and study plan

Primary outcomes

  1. 28 days in-hospital mortality

    Time frame: October 1, 2022 and June 30, 2023

    28 days in hospital mortality in patients with sepsis or septic shock

Secondary outcomes

  1. The prevalence of right ventricular systolic dysfunction

    Time frame: October 1, 2022 and June 30, 2023

    The prevalence of right ventricular systolic dysfunction in patients with sepsis and septic shock

  2. Blood lactate levels

    Time frame: October 1, 2022 and June 30, 2023

    Blood lactate levels in patients with sepsis and septic shock

  3. Lenght of ICU stay

    Time frame: October 1, 2022 and June 30, 2023

    Lenght of ICU stay in patients with sepsis and septic shock

  4. Duration of mechanical ventilation

    Time frame: October 1, 2022 and June 30, 2023

    Duration of mechanical ventilation in patients with sepsis and septic shock

Sponsors and collaborators

Lead sponsor

Burapha University

Other

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jan 5, 2024
Registry last updated
Jan 5, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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