The Prevalence of Neurocognitive Disorder in a Primary Care-based HIV Cohort Compared to a HIV-negative Control Cohort -

HIV positive Inclusion Criteria:

• Documented HIV infection
• Able to participate in study procedures

HIV positive Exclusion Criteria:

• Inability to comprehend or read English (as established by the English proficiency questionnaire)
• Drug or alcohol intoxicated (as determined by the investigator)
• Lack of information in medical records to determine the HAND predictive algorithm (current CD4 count, past CNS HIV-related disease, and duration of HIV therapy)
• Life expectancy <6 months
• Inability to attend the clinic for required study follow up visits

HIV-negative Inclusion Criteria:

• Negative HIV-1 test within 12 months of study entry

HIV-negative Exclusion Criteria:

• Life time traumatic brain injury leading to loss of consciousness of at least 30 minutes.
• Inability to comprehend or read English (as established by the English proficiency questionnaire).
• Inability to attend the clinic for required study follow up visits.
• History of chronic neurological illness.
• Unstable psychiatric conditions such as bipolar disorder or depression.
• Individuals with psychiatric disorder on the psychotic axis.
• Active or past (within the last 6 months) severe alcohol or substance abuse sufficient, in the investigator's judgement, to prevent completion of tests or Inability to attend for the planned required study follow up visits.