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OpenTrials
Completed

NCT Number: NCT02271620

The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

* To determine prevalence of local allergic rhinitis (LAR) * To evaluate clinical characteristic and severity of local allergic rhinitis * To measure changing of tryptase and Specific IgE for Dermatophagoides pteronyssinus (Dp) after nasal allergen provocation test (NAPT)

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Key information

Conditions

Other Allergic Rhinitis

Age range

8 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Division of allergy and immunology, Department of pediatric, Siriraj Hospital, Bangkoknoi, Bangkok, Thailand

Loading trial locations.

About this study

Children 8-18 years with NAR were recruited. A NAPT with Der p 1 solutions (NAPT-DP) at 200 AU/mL, 600 AU/mL and 2000 AU/mL at 15-minute interval was performed, respectively. The immediate responses to NAPT-DP were assessed using symptoms score, peak nasal inspiratory flow (PNIF) and acoustic rhinometry (ARM). The nasal tryptase and sIgE-DP were measured at baseline, 15 min and 1 h after positive NAPT-DP. Allergic rhinitis (AR) patients were used as positive control.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children 8-15 years who were diagnosed with nonallergic rhinitis (NAR) at least 1 year
  • No respiratory infections in the previous 4 weeks
  • No following treatment of
  • systemic corticosteroid 4 weeks
  • intranasal corticosteroid 2 weeks
  • oral antihistamine 1 week
  • leukotriene antagonist 1 week

Exclusion criteria

  • Patients with underlying disease:
  • chronic rhinosinusitis and nasal polyp
  • immunological disease
  • chronic renal disease
  • hepatobiliary disease
  • cardiovascular disease
  • cancer
  • Parental withdraw consent
  • Patient with uncontrolled asthma, peak expiratory flow rate (PEFR) < 80% of predicted

Treatment and study plan

nasal allergen provocation test

Procedure

nasal allergen provocation test

Primary outcomes

  1. prevalence of local allergic rhinitis (LAR)

    Time frame: 1 year

    positive nasal allergen provocation test with Der p1

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Oct 22, 2014
Registry last updated
Mar 22, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.