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Completed

NCT Number: NCT01457534

The Predictors for Continuous Renal Replacement Therapy in Liver Transplant Patient

Background. Acute renal failure after liver transplantation (LT) requiring continuous renal replacement therapy (CRRT) adversely affects patient survival. However, there are few reports to assess the predictors for postoperative CRRT in liver transplant patients. The investigators undertook this study to identify perioperative factors that would predict patients at risk of CRRT.

Patients and Methods. The investigators retrospectively reviewed the data of 148 liver transplant patients from January 2007 to November 2010 at Severance Hospital, Yonsei University HealthSystem, in Seoul, Korea. The number of patients treated with CRRT was 44 (18 patients from living and 26 from deceased donors) and those without CRRT was 104. Univariate and stepwise logistic multivariate analyses were performed.

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Key information

Conditions

Liver Transplantation

Age range

19 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Severance Hospital

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 19-65 year
  • Liver transplant patients from January 2008 to December 2011

Exclusion criteria

  • Patients treated with CRRT before transplantation

Treatment and study plan

Primary outcomes

  1. status before operation

    Time frame: 1 day before operation

    laboratory data(ex : total bilirubin, albumin, coagulation factors, blood gas analysis(arterial CO2 pressure. Blood urea nitrate/Creatinine, Hemoglobin/Hematocrit.)

  2. the amount of ascites

    Time frame: intraoperative

  3. the duration of anesthesia and operation

    Time frame: intraoperative

  4. intraoperative hemodynamic instability

    Time frame: intraoperative

  5. intraoperative bleeding

    Time frame: intraoperative

  6. Intraoperative urine output

    Time frame: intraoperative

  7. the types of donation(living or deceased donor)

    Time frame: intraoperative

  8. survival rate

    Time frame: on the postoperative 28th days, 365 days

  9. postoperative bleeding amount

    Time frame: on the postoperative 28th days, 365 days.

  10. postoperative CRRT(continuous renal replacement therapy),

    Time frame: on the postoperative 28th days, 365days

  11. mortality

    Time frame: on the postoperative 28th days, 365 days.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2011
Primary completion
2011
Study completion
2011
First posted
Oct 24, 2011
Registry last updated
Feb 27, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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