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NCT Number: NCT06919484

The Physiological Effect of RCexp on Ventilation/Perfusion Distribution

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

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Key information

Conditions

Acute Respiratory Distress Syndrome Lung Diseases Mechanical Ventilation Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongda Hospital, School of Medicine, Southeast University

Nanjing, Jiangsu, 210009, China

Location status: Recruiting

Location contact

yan xue yuan

CONTACT

[email protected]

032-83262550

About this study

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult patients with ARDS receiving mechanical ventilation no more than 72 hours

Exclusion criteria

  • age <18 years old
  • patient undergoing legal protection
  • contra-indications to EIT (e. g. severe chest trauma or wounds)
  • pneumothorax
  • patient undergoing ECMO
  • pregnancy

Treatment and study plan

RCexp

Other

patients received different RCexp

Primary outcomes

  1. Difference in ventilation/perfusion mismatch

    Time frame: 4 hours

    ventilation/perfusion mismatch is measured by EIT

Secondary outcomes

  1. Difference in dead space

    Time frame: 4 hours

    dead space is measured by EIT

  2. Difference in shunt

    Time frame: 4 hours

    shunt is measured by EIT

Study contacts

Contact information is provided by the study sponsor or research team.

yuan xue yan, MD

CONTACT

[email protected]

+86-15901599659

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

The Physiological Effect of RCexp on Ventilation/Perfusion Distribution in Patients With ARDS

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 9, 2025
Registry last updated
Nov 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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