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OpenTrials
Completed

NCT Number: NCT04622384

The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning

Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT).

Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.

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Key information

Conditions

Acute Kidney Injury Acute Kidney Failure Stage 3 Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Aarhus University Hospital, Department of Anaesthesiology

Aarhus, 8200, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients ≥ 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning

Exclusion criteria

  • Insufficient ultrasonographic imaging of the kidneys
  • Known morphological kidney disease
  • Previous need of chronic RRT
  • Prior participation in the study
  • Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device

Treatment and study plan

Dialysis weaning

Other

Dialysis weaning as planned by the attending ICU-physician.

Primary outcomes

  1. Dialysis weaning

    Time frame: 7 days

    If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days.

Secondary outcomes

  1. Renal Doppler arterial Resistive Index (RI)

    Time frame: Measured at the beginning of weaning and after 6 hours.

    Measured in the interlobar vessels

  2. Renal Doppler Renal Venous Stasis Index (RVSI)

    Time frame: Measured at the beginning of weaning and after 6 hours.

    Measured in the interlobar vessels

  3. Renal Doppler Venous Impedance Index (VII)

    Time frame: Measured at the beginning of weaning and after 6 hours.

    Measured in the interlobar vessels

  4. Portal vein Doppler Pulsatility Fraction PF)

    Time frame: Measured at the beginning of weaning and after 6 hours.

    Measured in the interlobar vessels

  5. Urine Output

    Time frame: 4 days

  6. Urine Creatinine Clearance

    Time frame: 4 days

Sponsors and collaborators

Lead sponsor

Johan Fridolf Hermansen

Other

Registry information

Important dates

Study start
2021
Primary completion
2023
Study completion
2023
First posted
Nov 10, 2020
Registry last updated
Mar 21, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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