The Oncoflavour Study

Oral nutritional supplements (ONS) are often prescribed for malnourished patients to help improve nutritional status. Commonly in cancer patients taste and smell alterations and side effects of treatment can affect the palatability and compliance to ONS. A variety of flavours and styles are available of ONS however research of the palatability of these in cancer patients is limited. This study aims to evaluate specific flavours created based on the taste changes occuring during treatment.

We aim to evaluate the patient liking and evaluation of 5 flavors in 3 different types of flavour-sensations:

* Warming/spicy sensation: to trigger the senses and bring new sensations * Cooling/fresh sensation: to have a fresh mouthfeel and lighter base perception * Neutral: to avoid that patients experience additional flavour and let them the opportunity to mix it with other food

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Key information

Conditions

Cancer Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Medical Center Groningen

Groningen, 9713 GZ, Netherlands

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

> 18 years old
Ability to complete and comprehend questionnaires provided
Undergoing systemic cancer treatment (chemotherapy or concurrent chemoradiotherapy, radiotherapy, targeted therapy or immunotherapy)

Exclusion criteria

Uncertainty about the willingness or ability of the patient to comply with the protocol requirements (no impairment and no cognitive impairments)
Coexisting-morbidities affecting taste or smell function
Lactose Intolerance or Galactosaemia
Dysphagia
Diabetics
Food allergies/intolerances to ingredients present in the product
No rejection of lemon, red fruits, exotic fruit, yellow fruit flavours.

Treatment and study plan

Tasting of flavours

Other

Each patient will taste 5 products, in sequential-monadic test, randomized, one by one.
Patients will take few sips of each study product, ideally in isolation (avoid influence of other patients)
For each product tasted the subjects will be asked to answer a questionnaire including 1 question on the palatability of the product using a 10-point hedonic scale and a more detailed organoleptic evaluation of the product.
Between product tastings, participants will have a 10 minutes break to rinse their mouth and fill in a questionnaire assessing sensory changes

Primary outcomes

Liking of 5 different oral nutritional supplements with adapted flavors

Time frame: 20 minutes

To evaluate patient liking and perception about 5 new flavors on a 10-point scale via a sip test

Sponsors and collaborators

Lead sponsor

University Medical Center Groningen

Other

Collaborators

Nutricia, Inc.

Registry information

Official study title

Product Validation by Cancer Patients - Oncoflavour

Important dates

Study start: 2017
Primary completion: 2017
Study completion: 2017
First posted: May 15, 2018
Registry last updated: Apr 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed