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NCT Number: NCT03335644

The NutriNet-Santé Study

The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior.

https://etude-nutrinet-sante.fr/ https://info.etude-nutrinet-sante.fr/en

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Key information

Conditions

Diet, Food, and Nutrition Adult Anthropometry Behavior Breast Feeding Cohort Studies Diseases Category Exercise Feeding Behavior Humans Internet Mortality Motor Activity Neoplasms Personal Satisfaction Psychological Well-Being Surveys and Questionnaires

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

EREN

Bobigny, Seine Saint Denis, 93017, France

Location status: Recruiting

Location contact

Allès Benjamin, Dr

SUB_INVESTIGATOR

Baudry Julia, Dr

SUB_INVESTIGATOR

Chantal Julia, Dr

SUB_INVESTIGATOR

Deschasaux Mélanie, Dr

SUB_INVESTIGATOR

Emmanuelle Kesse-Guyot, Dr

SUB_INVESTIGATOR

Léopold Fezeu, Dr

SUB_INVESTIGATOR

Mathilde Touvier, Dr

CONTACT

[email protected]

+33148388933

Pilar Galan, Dr

SUB_INVESTIGATOR

Sandrine Péneau, Dr

SUB_INVESTIGATOR

Serge Hercberg, Pr

SUB_INVESTIGATOR

Valentina Andreeva, Dr

SUB_INVESTIGATOR

About this study

NutriNet-Santé is a large-scale (n=171,000) web-based cohort coordinated by EREN, launched in France in 2009 to investigate nutrition and health relationships. All required ethics authorisations have been obtained (listed here). NutriNet-Santé participants regularly fill questionnaires through a dedicated and secure website, providing extensive, high-quality nutritional and non-nutritional data, including repeated data on socio-demographics and lifestyle (yearly), anthropometrics (every 6 months), dietary intake (every 6 months), physical activity (IPAQ questionnaire, yearly)5 and health status (every 6 months). NutriNet-Santé is characterised by a very detailed and up-to-date assessment of nutritional exposure and dietary behaviours. Usual dietary intakes are assessed at baseline and every 6 months thereafter through a series of 3 non-consecutive randomly assigned 24h dietary records. Daily energy, alcohol, micro- and macronutrient intakes are calculated using the published NutriNet-Santé food composition database (>3,500 generic items). All major health events (e.g., cancers, cardio- and cerebrovascular diseases) are reported by the participants and validated by an expert committee of physicians based on medical records, and/or retrieved from the French National Health Insurance medico-administrative databases to limit potential reporting bias. In turn, mortality data are obtained from the exhaustive French National Mortality Registry (CépiDC). The number of incident events already registered is as follows: 4,200 cancers and 1,240 deaths. A sub-sample of the cohort (n=20,000) provided blood and urine samples, currently stored at -80°C in EREN's biobank.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged over 15 years
  • access to internet

Exclusion criteria

  • aged under 15 years

Treatment and study plan

Primary outcomes

  1. cancers using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  2. CVD using health questionnaire and/or the dedicated website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  3. type 2 diabetes using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  4. hypertension using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  5. metabolic syndrome using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  6. depression using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  7. migraine using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  8. rheumatoid arthritis using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  9. cognitive decline using health questionnaire and/or the website for declaration of major health events

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  10. quality of life using the SF-36 questionnaire

    Time frame: every 6 months after registration, up to 10 years of follow-up

    self reported

  11. Weight using anthropometric questionnaire

    Time frame: every year after registration, up to 10 years of follow-up

    self reported

  12. Height using anthropometric questionnaire

    Time frame: every year after registration, up to 10 years of follow-up

    self reported

  13. Mortality

    Time frame: continuously updated

    CepiDC exhaustive national registry

  14. Mental health (incl. anxious disorders, sleep disorders, addictive behaviors, eating disorders)

    Time frame: repeatedly during followup

    self reported though validated scales and/or questionnaires

  15. SARSCOV-2 (Covid 19) infection

    Time frame: regular update for a subsampe of the cohort from 2020

    serology + questionnaires on symptoms

  16. multi-morbidity (mental and physical health)

    Time frame: continuous update

    combination of previsously listed mental and physical health outcomes

Study contacts

Contact information is provided by the study sponsor or research team.

Mathilde Touvier, Dr

CONTACT

[email protected]

+33148388933

Sponsors and collaborators

Lead sponsor

University of Paris 13

Other

Collaborators

  • Conservatoire national des Arts et Métiers
  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
  • Institut National de la Santé Et de la Recherche Médicale, France

Registry information

Official study title

The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors

Important dates

Study start
2009
Primary completion
2029
Study completion
2029
First posted
Nov 8, 2017
Registry last updated
Jul 26, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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