The Neurobehavioral Effects of Anesthetics on Infants With Hearing Impairment（Retrospective Research）

Gesell development scale contains five subscales including adaptability, fine motor, gross motor, language, and social skill evaluation. Developmental quotient (DQ) = (development age/actual age)×100. Total DQ is the average of five DQ of subscales. DQ≥86 is normal, 76≤DQ≤85 is suspicious, 55≤DQ≤75 is mild neurological damage, 40≤DQ ≤54 is moderate neurological damage, 25 B DQ B 39 is severe neurological damage, and DQ< 25 is very severe neurological damage.

Inclusion criteria

• Children undergoing cochlear implantation under general anesthesia
• 6 to 36-month-old child
• Normal body weight
• Children with normal structures of the inner ear and auditory nerve
• Children without contraindications to anesthesia and surgery
• Patients who have not participated in other clinical trials
• Without any acute infectious diseases or systematic diseases

Exclusion criteria

• The participants with a Gesell score (fine motor and gross motor) lower than 86 after preoperative evaluation.
• With other illness which could affects curative effect of recovery, such as inner ear malformations (except for large vestibular aqueduct syndrome), auditory vestibular nerve dysplasia, dysgnosia and mental disease;
• Inability to cooperate with the hearing evaluation and the language training
• Cute and chronic otitis media and mastoiditis, unhealed tympanic membrane perforation
• Abnormal structure of brain, including white matter dysplasia, Demyelinating Diseases