Skip to main content
OpenTrials
Completed

NCT Number: NCT03104257

The Neural Correlates of Cannabis Use

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Cannabis Dependence Chemically-Induced Disorders Healthy Marijuana Abuse Mental Disorders Substance-Related Disorders

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Conneticut Mental Health Center

New Haven, Connecticut, 06519, United States

About this study

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed outpatient abstinence (confirmed by tracking creatinine adjusted urine THC-COOH levels). This research will also examine associations between CB1R availability, neural oscillations and cognitive function using [11-C]OMAR PET imaging and electroencephalography.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cannabis Dependent Subjects

  • Current cannabis consumption
  • Willing to abstain from cannabis use for four weeks

Inclusion criteria

for Healthy Controls

  • No current cannabis consumption

Exclusion criteria

  • MRI metal exclusions and claustrophobia
  • Education completed is less than 12 years

Treatment and study plan

[11-C]OMAR

Drug

The radiotracer, [11-C]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Primary outcomes

  1. CB1R availability using [11-C]OMAR PET imaging

    Time frame: Change in CB1R availability from baseline to 48 hours and 28 days

    Change in CB1R availability (e.g. volume distribution).

Secondary outcomes

  1. Changes in Cognition during withdrawal using a computerized battery

    Time frame: Change in CB1R availability from baseline to 48 hours and 28 days

    Changes in cognitive functions such as attention, memory, motor functioning, and processing speed.

  2. Changes in brain rhythms measured by Electroencephalography

    Time frame: Change in CB1R availability from baseline to 48 hours and 28 days

    Changes in electroencephalographic (EEG) brain rhythms related to information processing.

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Acronym: Multimodal

Important dates

Study start
2016
Primary completion
2022
Study completion
2022
First posted
Apr 7, 2017
Registry last updated
Oct 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.