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OpenTrials
Completed

NCT Number: NCT01552564

The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

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Key information

Conditions

STEMI Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Bristol Heart Institute

Bristol, BS2 8HW, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • >18 years old
  • Cardiac symptoms of > 20 mins chest pain or equivalent.
  • ECG criteria consistent with STEMI (STEMI)
  • Proceeding with percutaneous angioplasty
  • Assent/ consent to the study

Exclusion criteria

  • Known allergy to adenosine or gadolinium
  • Chronic atrial fibrillation
  • Renal impairment with eGFR <30
  • Contraindication to angiography
  • Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner)
  • Cardiogenic shock
  • Patients with special communication needs or altered consciousness.
  • Patients who do not give assent/consent to the study

Treatment and study plan

index of microvascular resistance

Procedure

Cardiac magnetic resonance

Other

Blood markers

Other

Primary outcomes

  1. Microvascular obstruction

    Time frame: DAy 2-4

    Microvascular obstruction as a percentage of the left ventricle at 2-4 days.

Sponsors and collaborators

Lead sponsor

University of Bristol

Other

Registry information

Acronym: Micro-AMI

Important dates

Study start
2012
Primary completion
2014
First posted
Mar 13, 2012
Registry last updated
Oct 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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