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OpenTrials
Completed

NCT Number: NCT02446327

The Metabolic Road to Diastolic Heart Failure: Diastolic Heart Failure Study

The main objective is to replicate the validation of omics biomarkers of left ventricular diastolic dysfunction in patients with metabolic syndrome.

The aim was to recruit overall 750 patients in Europe (100 for France). Currently, 625 patients were enrolled in Europe and 47 in France.

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Key information

Conditions

Diastolic Heart Failure Cardiovascular Diseases Heart Diseases Heart Failure Heart Failure, Diastolic

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients 18 years of age or older
  • Signs or symptoms of HF
  • Able and willing to provide freely given written informed consent including analysis of genomics

Exclusion criteria

  • Patients with acute myocardial infarction
  • Recent trauma or surgery (< 3 months)
  • Hemodynamically significant valvular disease
  • Serious cerebrovascular disease or stroke in the last 3 months
  • Chronic dialysis
  • Chronic liver disease
  • Chronic infectious (bacterial or viral) disease
  • Any malignant concomitant diseases or a malignant disease in the last 5 years
  • Systemic inflammatory diseases, such as autoimmune diseases, connective tissue diseases or collagenoses
  • Pregnant women

Treatment and study plan

Blood sampling for biomarker assessment

Other

Primary outcomes

  1. Cardiovascular Hospitalizations or Cardiovascular Death

    Time frame: 12 months

Secondary outcomes

  1. Cardiovascular Hospitalizations

    Time frame: 3 months, 6 months, 12 months

  2. Heart Failure Hospitalizations

    Time frame: 3 months, 6 months, 12 months

  3. Other cardiovascular hospitalizations

    Time frame: 3 months, 6 months, 12 months

  4. Non cardiovascular hospitalizations

    Time frame: 3 months, 6 months, 12 months

  5. Cardiovascular Death

    Time frame: 3 months, 6 months, 12 months

  6. Non cardiovascular Death

    Time frame: 3 months, 6 months, 12 months

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Official study title

The Metabolic Road to Diastolic Heart Failure : Diastolic Heart Failure Study (MEDIA-DHF)

Acronym: MEDIA-DHF

Important dates

Study start
2012
Primary completion
2014
Study completion
2015
First posted
May 18, 2015
Registry last updated
Jun 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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