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NCT Number: NCT06808399

The Magnitude of Inter-limb Asymmetry and Its Assocation with Inter-limb Asymmetry in Distance Runners and Non-runners

Distance running is one of the most popular and most accessible ways to engage in physical activity. Although distance running offers numerous health-related benefits and protects against noncommunicable diseases (e.g., type 2 diabetic, obesity, hypertension), research has indicated a high prevalence of running-related injuries with a more pronounced incidence among novice runners (i.e., 17.8 injuries per 1000h) compared to their highly trained peers (i.e., 7.2 injuries per 1000h).

Interlimb asymmetry has previously been related to higher injury risk as well as to impaired sports performances. Nevertheless, to date, research on the degree and evolution of functional asymmetry (e.g., unequal strength between limbs) in distance runners is scarce and the role of functional asymmetries in running performance and running-related injuries remains unclear. Moreover, and despite the great number of unilateral tests available in the literature, there currently exists no reliable and run-specific field-based test battery to examine the degree of lower limb asymmetry in distance runners. Therefore, this study aims to assess the test-retest, intra- and inter-rater reliability of a newly created running-specific field-based test battery to assess the presence and degree of functional lower limb asymmetry among novice, moderatly and highly trained distance runners as well as a control group of non-athletes. The second objective is to assess the association between inter-limb asymmetry and running performance.

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Key information

Conditions

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

MOVE Research group

Ixelles-Elsene, Brussels Capital, 1050, Belgium

Location status: Recruiting

Location contact

Joachim D'Hondt

CONTACT

[email protected]

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Being aged between 20 and 50 years at Tfamiliarization
  • Being free from any medical attention injury (i.e., injury that results in a participant receiving medical attention) for at least 6 months upon Tfamiliarization
  • Speaking Dutch, French or English
  • Highly trained distance runners:
  • Running at least 150km per month for at least 3 months

Moderately-trained runners:

  • Running between 40 - 150 km per month for at least 6 months
  • Novice distance runners:
  • Running not more than 10km per week for the past 12 months
  • Control group of non-athletes
  • Performing <75min of systematic moderate to vigorous-intensity physical activity per week and having no experience in systematic (un)structured running activities for the past 5 years

Exclusion criteria

  • • Being younger than 20 years or older than 50 years at Tfamiliarization
  • Any known relevant medical history or current condition (e.g., neurological diseases, inner ear diseases) that could affect the performance of the functional tests (e.g., balance in repeated hop tests)
  • Participants that have undergone a surgery at lower limb level during the past 6 months
  • Medication or drug use (e.g., blood pressure medicines)that could affect the performance of the functional tests (e.g., balance in repeated hop tests)
  • Participants performing more than two hours per week of unilateral sports (e.g., tennis or soccer)

Treatment and study plan

Primary outcomes

  1. Lean mass

    Time frame: Baseline

    Measured using dual-energy X-ray absorptiometry.

  2. Fat mass

    Time frame: Baseline

    Measured using dual-energy X-ray absorptiometry.

  3. Bone mineral density

    Time frame: Baseline

    Measured using dual-energy X-ray absorptiometry.

  4. Phase angle

    Time frame: Baseline

    Measured using bioelectrical impedance analysis.

  5. Lean mass

    Time frame: Baseline

    Measured using bioelectrical impedance analysis.

  6. Fat mass

    Time frame: Baseline

    Measured using bioelectrical impedance analysis.

  7. Total segmental water

    Time frame: Baseline

    Measured using bioelectrical impedance analysis.

  8. Extracellular water

    Time frame: Baseline

    Measured using bioelectrical impedance analysis.

  9. 5 repeated vertical hop test.

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using an Optojump device

  10. 5 repeated horizontal hop test

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using an Optojump device

  11. ankle dorsiflexion range of motion

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    The maximal dorsiflexion range of motion (cm from a wall) will be measured with tape measure.

  12. Side bridge endurance test

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    The side bridge endurance test will be carried out in which, the participants will lie on one side of the body fully extended (i.e., hip and torso at 0°) in a plank position with the feet elevated on a 15-cm step and with the superior feet placed in front. The participants will be instructed to lift the hips until the body is in straight position with the arms folded across the chest. The time until a drop (lasting more than 3s) of the hips from the optimal position will manually be recorded. To control for a full range of motion upon the execution of this muscle capacity tests, a reference dowel will be used to indiciate the desired range of motion.

  13. Hip adduction strength

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured with a handheld dynamometer.

  14. Hip abduction strength

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using a hand-held dynamometer.

  15. Knee extension strength

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using a hand-held dynamometer.

  16. Knee flexion strength

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using a hand-held dynamometer.

  17. Ankle dorsiflexion strength

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using a hand-held dynamometer.

  18. Ankle plantar flexion strength

    Time frame: 3 test occasions: baseline, 2 weeks after baseline and 4 weeks after baseline.

    Measured using a hand-held dynamometer.

  19. Cooper test

    Time frame: This test will be carried out on the second test occasion (two weeks after baseline).

    Maximal distance covered in 12 minutes.

  20. Training volume

    Time frame: Baseline

    Surveyed with an online questionnaire and quantified in hours/week (per sport performed).

  21. Contact time while running

    Time frame: This test will be carried out on the third test occasion (four weeks after baseline).

    Measures with an Optojump device

  22. Flight time while running

    Time frame: This test will be carried out on the third test occasion (four weeks after baseline).

    Measured using an Optojump device.

  23. Stride length

    Time frame: This test will be carried out on the third test occasion (four weeks after baseline).

    Measured using an Optojump device.

Secondary outcomes

  1. Weight

    Time frame: Baseline

  2. Height

    Time frame: Baseline

  3. Leg length

    Time frame: Baseline

    Measured using dual-energy X-ray absorptiometry and a tape measure.

  4. Bone mineral content

    Time frame: Baseline

    Measured busing dual-energy X-ray absorptiometry.

Study contacts

Contact information is provided by the study sponsor or research team.

Joachim D'Hondt

CONTACT

[email protected]

+32 (0) 629 27 35

Sponsors and collaborators

Lead sponsor

Vrije Universiteit Brussel

Other

Registry information

Official study title

Lower Limb Functional Asymmetry in Healthy Novice, Moderately and Highly-trained Distance Runners Versus Non-athletes

Acronym: ASYMRUN

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Feb 5, 2025
Registry last updated
Feb 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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