The Longterm Risk of Advanced Colorectal Neoplasia After Colonoscopy - A Population-based Cohort Study in Hong Kong

The primary objective of this study is to analyze the 15-year cumulative incidence of advanced colorectal neoplasia and CRC-related mortality after the index colonoscopy.

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Key information

Conditions

Colorectal Neoplasia Colonic Diseases Colorectal Cancer Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Rectal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Prince of Wales Hospital

Shatin, New Territories, Hong Kong

Location status: Recruiting

About this study

This is a territory-wide retrospective observational cohort study using the Clinical Data Analysis and Reporting System (CDARS). We will identify patients from CDARS with colonoscopy performed from 1 January 2000 to 31 October 2020. Other relevant diagnoses, procedures, concomitant drugs, laboratory parameters and pathology results will be retrieved and studied.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients with colonoscopy performed in HA hospitals during the study period would be eligible for screening.

Exclusion criteria

Patients with documented personal history of colorectal cancers before the study period would be excluded.

Treatment and study plan

Primary outcomes

Culumative incidence of advanced colorectal neoplasia

Time frame: 15 years

high-risk adenomas or CRC after 15 years of index conoloscopy

Secondary outcomes

CRC-related mortality rate

Time frame: 15 years

the rate of mortality due to CRC-related incidents

Study contacts

Contact information is provided by the study sponsor or research team.

Felix Sia

CONTACT

[email protected]

+85226370428

Thomas Lam

CONTACT

[email protected]

+85226370428

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Acronym: ACNC

Important dates

Study start: 2023
Primary completion: 2026
Study completion: 2026
First posted: Mar 25, 2021
Registry last updated: Feb 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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